Autotransplant conditioning regimens for aggressive lymphoma

Are we on the right road?

H. F. Fernandez, M. P. Escalón, Denise L Pereira, H. M. Lazarus

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

High-dose chemotherapy and autologous stem cell transplant (ASCT) is the standard approach for chemosensitive, relapsed aggressive non-Hodgkin's lymphoma (NHL). Various conditioning regimens have been used as treatment before ASCT and disease-free (DFS) and overall survival (OS) rates range from 34 to 60% and 26 to 46%, respectively. To date, few comparative randomized trials have been performed and no regimen has demonstrated superiority to another. Reduction of disease relapse remains the major hurdle for improving patient outcome and in vitro and in vivo purging of lymphoma cells has not necessarily enhanced results. Rituximab pre-mobilization and post-transplant appear to provide better response rates with OS approaching 87-91% at 2-3 years. Newer approaches with radioimmunotherapy may raise DFS to 78% and OS to 93%, albeit with short follow-up. Advances in the conditioning regimens and supportive care have reduced transplant-related mortality to less than 10%. In this review we discuss commonly utilized conditioning regimens, describe their pros and cons and address purging and present conditioning strategies. Owing to the poor outcome with conventional chemotherapy in mantle cell, Burkitt's and T-cell lymphoma, we propose the standard approach of front-line ASCT for these high-risk lymphoma patients. Finally, we will present novel strategies, which can enhance the anti-lymphoma effect, at the same time reducing toxicity, to improve the outcome of ASCT in NHL patients.

Original languageEnglish
Pages (from-to)505-513
Number of pages9
JournalBone Marrow Transplantation
Volume40
Issue number6
DOIs
StatePublished - Sep 1 2007

Fingerprint

Autografts
Lymphoma
Transplants
Stem Cells
Non-Hodgkin's Lymphoma
Radioimmunotherapy
Drug Therapy
Survival
T-Cell Lymphoma
Survival Rate
Recurrence
Mortality

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Autotransplant conditioning regimens for aggressive lymphoma : Are we on the right road? / Fernandez, H. F.; Escalón, M. P.; Pereira, Denise L; Lazarus, H. M.

In: Bone Marrow Transplantation, Vol. 40, No. 6, 01.09.2007, p. 505-513.

Research output: Contribution to journalArticle

Fernandez, H. F. ; Escalón, M. P. ; Pereira, Denise L ; Lazarus, H. M. / Autotransplant conditioning regimens for aggressive lymphoma : Are we on the right road?. In: Bone Marrow Transplantation. 2007 ; Vol. 40, No. 6. pp. 505-513.
@article{9e3543e86ef643c5bb669c790c755d65,
title = "Autotransplant conditioning regimens for aggressive lymphoma: Are we on the right road?",
abstract = "High-dose chemotherapy and autologous stem cell transplant (ASCT) is the standard approach for chemosensitive, relapsed aggressive non-Hodgkin's lymphoma (NHL). Various conditioning regimens have been used as treatment before ASCT and disease-free (DFS) and overall survival (OS) rates range from 34 to 60{\%} and 26 to 46{\%}, respectively. To date, few comparative randomized trials have been performed and no regimen has demonstrated superiority to another. Reduction of disease relapse remains the major hurdle for improving patient outcome and in vitro and in vivo purging of lymphoma cells has not necessarily enhanced results. Rituximab pre-mobilization and post-transplant appear to provide better response rates with OS approaching 87-91{\%} at 2-3 years. Newer approaches with radioimmunotherapy may raise DFS to 78{\%} and OS to 93{\%}, albeit with short follow-up. Advances in the conditioning regimens and supportive care have reduced transplant-related mortality to less than 10{\%}. In this review we discuss commonly utilized conditioning regimens, describe their pros and cons and address purging and present conditioning strategies. Owing to the poor outcome with conventional chemotherapy in mantle cell, Burkitt's and T-cell lymphoma, we propose the standard approach of front-line ASCT for these high-risk lymphoma patients. Finally, we will present novel strategies, which can enhance the anti-lymphoma effect, at the same time reducing toxicity, to improve the outcome of ASCT in NHL patients.",
author = "Fernandez, {H. F.} and Escal{\'o}n, {M. P.} and Pereira, {Denise L} and Lazarus, {H. M.}",
year = "2007",
month = "9",
day = "1",
doi = "10.1038/sj.bmt.1705744",
language = "English",
volume = "40",
pages = "505--513",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Autotransplant conditioning regimens for aggressive lymphoma

T2 - Are we on the right road?

AU - Fernandez, H. F.

AU - Escalón, M. P.

AU - Pereira, Denise L

AU - Lazarus, H. M.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - High-dose chemotherapy and autologous stem cell transplant (ASCT) is the standard approach for chemosensitive, relapsed aggressive non-Hodgkin's lymphoma (NHL). Various conditioning regimens have been used as treatment before ASCT and disease-free (DFS) and overall survival (OS) rates range from 34 to 60% and 26 to 46%, respectively. To date, few comparative randomized trials have been performed and no regimen has demonstrated superiority to another. Reduction of disease relapse remains the major hurdle for improving patient outcome and in vitro and in vivo purging of lymphoma cells has not necessarily enhanced results. Rituximab pre-mobilization and post-transplant appear to provide better response rates with OS approaching 87-91% at 2-3 years. Newer approaches with radioimmunotherapy may raise DFS to 78% and OS to 93%, albeit with short follow-up. Advances in the conditioning regimens and supportive care have reduced transplant-related mortality to less than 10%. In this review we discuss commonly utilized conditioning regimens, describe their pros and cons and address purging and present conditioning strategies. Owing to the poor outcome with conventional chemotherapy in mantle cell, Burkitt's and T-cell lymphoma, we propose the standard approach of front-line ASCT for these high-risk lymphoma patients. Finally, we will present novel strategies, which can enhance the anti-lymphoma effect, at the same time reducing toxicity, to improve the outcome of ASCT in NHL patients.

AB - High-dose chemotherapy and autologous stem cell transplant (ASCT) is the standard approach for chemosensitive, relapsed aggressive non-Hodgkin's lymphoma (NHL). Various conditioning regimens have been used as treatment before ASCT and disease-free (DFS) and overall survival (OS) rates range from 34 to 60% and 26 to 46%, respectively. To date, few comparative randomized trials have been performed and no regimen has demonstrated superiority to another. Reduction of disease relapse remains the major hurdle for improving patient outcome and in vitro and in vivo purging of lymphoma cells has not necessarily enhanced results. Rituximab pre-mobilization and post-transplant appear to provide better response rates with OS approaching 87-91% at 2-3 years. Newer approaches with radioimmunotherapy may raise DFS to 78% and OS to 93%, albeit with short follow-up. Advances in the conditioning regimens and supportive care have reduced transplant-related mortality to less than 10%. In this review we discuss commonly utilized conditioning regimens, describe their pros and cons and address purging and present conditioning strategies. Owing to the poor outcome with conventional chemotherapy in mantle cell, Burkitt's and T-cell lymphoma, we propose the standard approach of front-line ASCT for these high-risk lymphoma patients. Finally, we will present novel strategies, which can enhance the anti-lymphoma effect, at the same time reducing toxicity, to improve the outcome of ASCT in NHL patients.

UR - http://www.scopus.com/inward/record.url?scp=34548531511&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548531511&partnerID=8YFLogxK

U2 - 10.1038/sj.bmt.1705744

DO - 10.1038/sj.bmt.1705744

M3 - Article

VL - 40

SP - 505

EP - 513

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - 6

ER -