Autoregulation of RNase E synthesis in Escherichia coli.

C. Jain, J. G. Belasco

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


RNase E plays a central role in controlling mRNA degradation in E. coli. We have investigated the mechanism of RNase E autoregulation. Our data indicate that RNase E autoregulates its synthesis by controlling the decay rate of its own transcript (rne mRNA), which is unusually sensitive to the level of cellular RNase E activity. Feedback regulation is mediated in cis by the rne 5' untranslated region (5' UTR), which can confer this property onto heterologous mRNAs to which it is fused. The marked sensitivity of rne mRNA to regulation by RNase E is also due in part to the susceptibility of nascent rne transcripts to RNase E-mediated degradation.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
JournalNucleic acids symposium series
Issue number33
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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