Autophagy maintains the metabolism and function of young and old stem cells

Theodore T. Ho, Matthew R. Warr, Emmalee R. Adelman, Olivia M. Lansinger, Johanna Flach, Evgenia V. Verovskaya, Maria Figueroa, Emmanuelle Passegué

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

With age, haematopoietic stem cells lose their ability to regenerate the blood system, and promote disease development. Autophagy is associated with health and longevity, and is critical for protecting haematopoietic stem cells from metabolic stress. Here we show that loss of autophagy in haematopoietic stem cells causes accumulation of mitochondria and an activated metabolic state, which drives accelerated myeloid differentiation mainly through epigenetic deregulations, and impairs haematopoietic stem-cell self-renewal activity and regenerative potential. Strikingly, most haematopoietic stem cells in aged mice share these altered metabolic and functional features. However, approximately one-third of aged haematopoietic stem cells exhibit high autophagy levels and maintain a low metabolic state with robust long-term regeneration potential similar to healthy young haematopoietic stem cells. Our results demonstrate that autophagy actively suppresses haematopoietic stem-cell metabolism by clearing active, healthy mitochondria to maintain quiescence and stemness, and becomes increasingly necessary with age to preserve the regenerative capacity of old haematopoietic stem cells.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalNature
Volume543
Issue number7644
DOIs
StatePublished - Mar 9 2017

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Autophagy
Hematopoietic Stem Cells
Stem Cells
Mitochondria
Physiological Stress
Epigenomics
Regeneration
Health

ASJC Scopus subject areas

  • General

Cite this

Ho, T. T., Warr, M. R., Adelman, E. R., Lansinger, O. M., Flach, J., Verovskaya, E. V., ... Passegué, E. (2017). Autophagy maintains the metabolism and function of young and old stem cells. Nature, 543(7644), 205-210. https://doi.org/10.1038/nature21388

Autophagy maintains the metabolism and function of young and old stem cells. / Ho, Theodore T.; Warr, Matthew R.; Adelman, Emmalee R.; Lansinger, Olivia M.; Flach, Johanna; Verovskaya, Evgenia V.; Figueroa, Maria; Passegué, Emmanuelle.

In: Nature, Vol. 543, No. 7644, 09.03.2017, p. 205-210.

Research output: Contribution to journalArticle

Ho, TT, Warr, MR, Adelman, ER, Lansinger, OM, Flach, J, Verovskaya, EV, Figueroa, M & Passegué, E 2017, 'Autophagy maintains the metabolism and function of young and old stem cells', Nature, vol. 543, no. 7644, pp. 205-210. https://doi.org/10.1038/nature21388
Ho TT, Warr MR, Adelman ER, Lansinger OM, Flach J, Verovskaya EV et al. Autophagy maintains the metabolism and function of young and old stem cells. Nature. 2017 Mar 9;543(7644):205-210. https://doi.org/10.1038/nature21388
Ho, Theodore T. ; Warr, Matthew R. ; Adelman, Emmalee R. ; Lansinger, Olivia M. ; Flach, Johanna ; Verovskaya, Evgenia V. ; Figueroa, Maria ; Passegué, Emmanuelle. / Autophagy maintains the metabolism and function of young and old stem cells. In: Nature. 2017 ; Vol. 543, No. 7644. pp. 205-210.
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