Abstract
Autonomic dysfunction in persons with acquired immune deficiency syndrome (AIDS) has been reported previously but its incidence in early stage HIV infection and its relation to cardiovascular function have not been fully examined. The present study evaluated cardiovascular and autonomic function in 55 HIV-seronegative, and 52 HIV-asymptomatic and 31 HIV-symptomatic seropositive men. Measures of hemodynamic and autonomic function were obtained at rest and during a standardized battery of autonomic tests. Results were compared across groups while controlling for age, body mass, and physical activity. Analyses indicated that measures of autonomic function did not differ among groups. However, at rest, both HIV seropositive groups exhibited diminished stroke volume and elevated diastolic blood pressure, albeit within normotensive levels. In addition, the ability to sustain a blood pressure response during prolonged challenge and the relationship between stroke volume and baroreceptor/vagal responsiveness were disrupted in the HIV-symptomatic group. Therefore, in the pre-AIDS stages of infection, autonomic functioning appeared intact; yet alterations in baroreceptor/vagal function associated with depressed myocardial function may be an early warning signal reflecting cardiovascular pathological processes potentially exacerbated by HIV spectrum disease.
| Original language | English |
|---|---|
| Pages (from-to) | 319-326 |
| Number of pages | 8 |
| Journal | Clinical Autonomic Research |
| Volume | 11 |
| Issue number | 5 |
| State | Published - Dec 10 2001 |
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Keywords
- AIDS
- Autonomic
- Cardiac output
- Cardiovascular
- HIV spectrum disease
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Autonomic and cardiovascular function in HIV spectrum disease : Early indications of cardiac pathophysiology. / Brownley, K. A.; Milanovich, J. R.; Motivala, S. J.; Schneiderman, Neil; Fillion, L.; Graves, J. A.; Klimas, N. G.; Fletcher, M. A.; Hurwitz, Barry.
In: Clinical Autonomic Research, Vol. 11, No. 5, 10.12.2001, p. 319-326.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autonomic and cardiovascular function in HIV spectrum disease
T2 - Early indications of cardiac pathophysiology
AU - Brownley, K. A.
AU - Milanovich, J. R.
AU - Motivala, S. J.
AU - Schneiderman, Neil
AU - Fillion, L.
AU - Graves, J. A.
AU - Klimas, N. G.
AU - Fletcher, M. A.
AU - Hurwitz, Barry
PY - 2001/12/10
Y1 - 2001/12/10
N2 - Autonomic dysfunction in persons with acquired immune deficiency syndrome (AIDS) has been reported previously but its incidence in early stage HIV infection and its relation to cardiovascular function have not been fully examined. The present study evaluated cardiovascular and autonomic function in 55 HIV-seronegative, and 52 HIV-asymptomatic and 31 HIV-symptomatic seropositive men. Measures of hemodynamic and autonomic function were obtained at rest and during a standardized battery of autonomic tests. Results were compared across groups while controlling for age, body mass, and physical activity. Analyses indicated that measures of autonomic function did not differ among groups. However, at rest, both HIV seropositive groups exhibited diminished stroke volume and elevated diastolic blood pressure, albeit within normotensive levels. In addition, the ability to sustain a blood pressure response during prolonged challenge and the relationship between stroke volume and baroreceptor/vagal responsiveness were disrupted in the HIV-symptomatic group. Therefore, in the pre-AIDS stages of infection, autonomic functioning appeared intact; yet alterations in baroreceptor/vagal function associated with depressed myocardial function may be an early warning signal reflecting cardiovascular pathological processes potentially exacerbated by HIV spectrum disease.
AB - Autonomic dysfunction in persons with acquired immune deficiency syndrome (AIDS) has been reported previously but its incidence in early stage HIV infection and its relation to cardiovascular function have not been fully examined. The present study evaluated cardiovascular and autonomic function in 55 HIV-seronegative, and 52 HIV-asymptomatic and 31 HIV-symptomatic seropositive men. Measures of hemodynamic and autonomic function were obtained at rest and during a standardized battery of autonomic tests. Results were compared across groups while controlling for age, body mass, and physical activity. Analyses indicated that measures of autonomic function did not differ among groups. However, at rest, both HIV seropositive groups exhibited diminished stroke volume and elevated diastolic blood pressure, albeit within normotensive levels. In addition, the ability to sustain a blood pressure response during prolonged challenge and the relationship between stroke volume and baroreceptor/vagal responsiveness were disrupted in the HIV-symptomatic group. Therefore, in the pre-AIDS stages of infection, autonomic functioning appeared intact; yet alterations in baroreceptor/vagal function associated with depressed myocardial function may be an early warning signal reflecting cardiovascular pathological processes potentially exacerbated by HIV spectrum disease.
KW - AIDS
KW - Autonomic
KW - Cardiac output
KW - Cardiovascular
KW - HIV spectrum disease
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M3 - Article
C2 - 11758799
AN - SCOPUS:0035178930
VL - 11
SP - 319
EP - 326
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
SN - 0959-9851
IS - 5
ER -