Automatic retinal blood flow calculation using spectral domain optical coherence tomography

Hassan Wehbe, Marco Ruggeri, Shuliang Jiao, Giovanni Gregori, Carmen A. Puliafito

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical Doppler tomography (ODT) is a branch of optical coherence tomography (OCT) that can measure the speed of a blood flow by measuring the Doppler shift impinged on the probing sample light by the moving blood cells. However, the measured speed of blood flow is a function of the Doppler angle, which needs to be determined in order to calculate the absolute velocity of the blood flow inside a vessel. We developed a technique that can extract the Doppler angle from the 3D data measured with spectral-domain OCT, which needs to extract the lateral and depth coordinates of a vessel in each measured ODT and OCT image. The lateral coordinates and the diameter of a blood vessel were first extracted in each OCT structural image by using the technique of blood vessel shadowgram, a technique first developed by us for enhancing the retinal blood vessel contrast in the en face view of the 3D OCT. The depth coordinate of a vessel was then determined by using a circular averaging filter moving in the depth direction along the axis passing through the vessel center in the ODT image. The Doppler angle was then calculated from the extracted coordinates of the blood vessel. The technique was applied in blood flow measurements in retinal blood vessels, which has potential impact on the study and diagnosis of blinding diseases like glaucoma and diabetic retinopathy.

Original languageEnglish (US)
Title of host publicationCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII
DOIs
StatePublished - Apr 21 2008
EventCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII - San Jose, CA, United States
Duration: Jan 21 2008Jan 23 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6847
ISSN (Print)1605-7422

Other

OtherCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII
CountryUnited States
CitySan Jose, CA
Period1/21/081/23/08

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Keywords

  • Angiogram
  • Blood flow
  • Blood vessels
  • Optical coherence tomography
  • Retina

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Wehbe, H., Ruggeri, M., Jiao, S., Gregori, G., & Puliafito, C. A. (2008). Automatic retinal blood flow calculation using spectral domain optical coherence tomography. In Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII [68470I] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6847). https://doi.org/10.1117/12.762404