Automated spectral analysis III: Application to in vivo proton MR spectroscopy and spectroscopic imaging

Brian J. Soher, Karl Young, Varanavasi Govindaraju, Andrew A. Maudsley

Research output: Contribution to journalArticlepeer-review

226 Scopus citations


An automated method for analysis of in vivo proton magnetic resonance (MR) spectra and reconstruction of metabolite distributions from MR spectroscopic imaging (MRSI) data is described. A parametric spectral model using acquisition specific, a priori information is combined with a wavelet- based, nonparametric characterization of baseline signals. For image reconstruction, the initial fit estimates were additionally modified according to a priori spatial constraints. The automated fitting procedure was applied to four different examples of MRS data obtained at 1.5 T and 4.1 T. For analysis of major metabolites at medium TE values, the method was shown to perform reliably even in the presence of large baseline signals and relatively poor signal-to-noise ratios typical of in vivo proton MRSI. Identification of additional metabolites was also demonstrated for short TE data. Automated formation of metabolite images will greatly facilitate and expand the clinical applications of MR spectroscopic imaging.

Original languageEnglish (US)
Pages (from-to)822-831
Number of pages10
JournalMagnetic Resonance in Medicine
Issue number6
StatePublished - Dec 1998
Externally publishedYes


  • Brain
  • In vivo MR spectroscopic imaging
  • Parametric spectral analysis
  • Proton

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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