Automated quantitation of choroidal neovascularization: A comparison study between spectral-domain and swept-source OCT angiograms

Qinqin Zhang, Chieh Li Chen, Zhongdi Chu, Fang Zheng, Andrew Miller, Luiz Roisman, Joao Rafael de Oliveira Dias, Zohar Yehoshua, Karen B. Schaal, William Feuer, Giovanni Gregori, Sophie Kubach, Lin An, Paul F. Stetson, Mary K. Durbin, Philip J. Rosenfeld, Ruikang K. Wang

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


PURPOSE. To compare the lesion sizes of choroidal neovascularization (CNV) imaged with spectral-domain (SD) and swept-source (SS) optical coherence tomography angiography (OCTA) and measured using an automated detection algorithm. METHODS. Patients diagnosed with CNV were imaged by SD-OCTA and SS-OCTA systems using 3 × 3-mm and 6 × 6-mm scans. The complex optical microangiography (OMAG C) algorithm was used to generate the OCTA images. Optical coherence tomography A datasets for imaging CNV were derived by segmenting from the outer retina to 8 lm below Bruch’s membrane. An artifact removal algorithm was used to generate angiograms free of retinal vessel projection artifacts. An automated detection algorithm was developed to quantify the size of the CNV. Automated measurements were compared with manual measurements. Measurements from SD-OCTA and SS-OCTA instruments were compared as well. RESULTS. Twenty-seven eyes from 23 subjects diagnosed with CNV were analyzed. No significant differences were detected between manual and automatic measurements: SD-OCTA 3 × 3-mm (P = 0.61, paired t-test) and 6 × 6-mm (P = 0.09, paired t-test) scans and the SS-OCTA 3 × 3-mm (P = 0.41, paired t-test) and 6 × 6-mm (P = 0.16, paired t-test) scans. Bland-Altman analyses were performed to confirm the agreement between automatic and manual measurements. Mean lesion sizes were significantly larger for the SS-OCTA images compared with the SD-OCTA images: 3 × 3-mm scans (P = 0.011, paired sample t-test) and the 6 × 6-mm scans (P = 0.021, paired t-test). CONCLUSIONS. The automated algorithm measurements of CNV were in agreement with the hand-drawn measurements. On average, automated SS-OCTA measurements were larger than SD-OCTA measurements and consistent with the results from using hand-drawn measurements.

Original languageEnglish (US)
Pages (from-to)1506-1513
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - Mar 2017


  • Macular neovascularization
  • Neovascular AMD
  • Optical coherence tomography
  • Pigment epithelium detachment
  • Spectral-domain OCTA
  • Swept-source OCTA

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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