Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

Alevtina Gall, Piper Treuting, Keith B. Elkon, Yueh Ming Loo, Michael Gale, Glen N. Barber, Daniel B. Stetson

Research output: Contribution to journalArticle

288 Scopus citations

Abstract

The type I interferon (IFN) response initiated by detection of nucleic acids is important for antiviral defense but is also associated with specific autoimmune diseases. Mutations in the human 3' repair exonuclease 1 (Trex 1) gene cause Aicardi-Goutières syndrome (AGS), an IFN-associated autoimmune disease. However, the source of the type I IFN response and the precise mechanisms of disease in AGS remain unknown. Here, we demonstrate that Trex1 is an essential negative regulator of the STING-dependent antiviral response. We used an invivo reporter of IFN activity in Trex 1-deficient mice to localize the initiation of disease to nonhematopoietic cells. These IFNs drove Tcell-mediated inflammation and an autoantibody response that targeted abundant, tissue-restricted autoantigens. However, B cells contributed to mortality independently of Tcell-mediated tissue damage. These findings reveal a stepwise progression of autoimmune disease in Trex1-deficient mice, with implications for the treatment of AGS and related disorders.

Original languageEnglish (US)
Pages (from-to)120-131
Number of pages12
JournalImmunity
Volume36
Issue number1
DOIs
StatePublished - Jan 27 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease'. Together they form a unique fingerprint.

  • Cite this