Autoimmune hepatitis and primary sclerosing cholangitis in children and adolescents

Claudia Patricia Rojas, Rajasekhar Bodicharla, German Campuzano-Zuluaga, Lina Hernandez, Maria Rodriguez

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Clinical presentation and histopathology of autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) overlap syndrome (OS) are similar, but their management is different. We conducted a pediatric retrospective cross-sectional study of 34 patients with AIH and PSC. AIH had female predominance (74%) and was lower in PSC (45%). There was a trend toward higher frequency of blacks in PSC/OS (55%) compared to Caucasians (36%) and Hispanics (9%), but not race differences in AIH. Inflammatory bowel disease (IBD) was present in 75% of PSC/OS. Plasma cells were not specific for AIH (found in 42% of PSC). Concentric fibrosis was not reliable for PSC as was found in 46% of AIH. Conclusion: A combination of clinical history, laboratory tests, imaging studies and liver biopsy are required to confirm and properly treat AIH and PSC. Liver biopsy should be used to grade severity and disease progression, but cannot be used alone to diagnose these conditions.

Original languageEnglish
Pages (from-to)202-209
Number of pages8
JournalFetal and Pediatric Pathology
Volume33
Issue number4
DOIs
StatePublished - Jan 1 2014

Fingerprint

Autoimmune Hepatitis
Sclerosing Cholangitis
Biopsy
Liver
Plasma Cells
Inflammatory Bowel Diseases
Hispanic Americans
Disease Progression
Fibrosis
Cross-Sectional Studies
Pediatrics

Keywords

  • Autoantibodies
  • Cholestasis
  • Cirrhosis
  • Hepatitis
  • Liver biopsy
  • Pediatric

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Rojas, C. P., Bodicharla, R., Campuzano-Zuluaga, G., Hernandez, L., & Rodriguez, M. (2014). Autoimmune hepatitis and primary sclerosing cholangitis in children and adolescents. Fetal and Pediatric Pathology, 33(4), 202-209. https://doi.org/10.3109/15513815.2014.898721

Autoimmune hepatitis and primary sclerosing cholangitis in children and adolescents. / Rojas, Claudia Patricia; Bodicharla, Rajasekhar; Campuzano-Zuluaga, German; Hernandez, Lina; Rodriguez, Maria.

In: Fetal and Pediatric Pathology, Vol. 33, No. 4, 01.01.2014, p. 202-209.

Research output: Contribution to journalArticle

Rojas, CP, Bodicharla, R, Campuzano-Zuluaga, G, Hernandez, L & Rodriguez, M 2014, 'Autoimmune hepatitis and primary sclerosing cholangitis in children and adolescents', Fetal and Pediatric Pathology, vol. 33, no. 4, pp. 202-209. https://doi.org/10.3109/15513815.2014.898721
Rojas, Claudia Patricia ; Bodicharla, Rajasekhar ; Campuzano-Zuluaga, German ; Hernandez, Lina ; Rodriguez, Maria. / Autoimmune hepatitis and primary sclerosing cholangitis in children and adolescents. In: Fetal and Pediatric Pathology. 2014 ; Vol. 33, No. 4. pp. 202-209.
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