Abstract
We consider the hypothesis that estrogen control of hormone dependent breast cancer is mediated by autocrine and paracrine growth factors secreted by the breast cancer cells themselves. Though we show direct, unmediated effects of estrogen on specific cell functions, we also provide evidence that human breast cancer cells secrete a collection of growth factors (IGF-I, TGFα, TGFβ, a PDGF-like competency factor, and at least one new epithelial colony stimulating factor). Some of these are estrogen-regulated in hormone dependent cells, and are constitutively increased in cells which acquire independence either spontaneously or by ras transfection. Collectively, the secreted growth factors are capable of promoting tumor formation by MCF-7 cells in nude mice, though not to the same extent as estrogens. There would seem to be potential for clinical intervention in the autocrine and paracrine control of breast cancer cells, including some cells which are no longer dependent on estrogens.
| Original language | English |
|---|---|
| Pages (from-to) | 59-70 |
| Number of pages | 12 |
| Journal | Breast Cancer Research and Treatment |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 1986 |
| Externally published | Yes |
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Keywords
- antiestrogen
- autocrine growth factors
- EGF
- hormone dependence
- IGF-I
- paracrine growth factors
- PDGF
- TGFα
- TGFβ
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Autocrine and paracrine growth regulation of human breast cancer. / Lippman, Marc E; Dickson, Robert B.; Bates, Susan; Knabbe, Cornelius; Huff, Karen; Swain, Sandra; McManaway, Mary; Bronzert, Diane; Kasid, Attan; Gelmann, Edward P.
In: Breast Cancer Research and Treatment, Vol. 7, No. 2, 01.06.1986, p. 59-70.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autocrine and paracrine growth regulation of human breast cancer
AU - Lippman, Marc E
AU - Dickson, Robert B.
AU - Bates, Susan
AU - Knabbe, Cornelius
AU - Huff, Karen
AU - Swain, Sandra
AU - McManaway, Mary
AU - Bronzert, Diane
AU - Kasid, Attan
AU - Gelmann, Edward P.
PY - 1986/6/1
Y1 - 1986/6/1
N2 - We consider the hypothesis that estrogen control of hormone dependent breast cancer is mediated by autocrine and paracrine growth factors secreted by the breast cancer cells themselves. Though we show direct, unmediated effects of estrogen on specific cell functions, we also provide evidence that human breast cancer cells secrete a collection of growth factors (IGF-I, TGFα, TGFβ, a PDGF-like competency factor, and at least one new epithelial colony stimulating factor). Some of these are estrogen-regulated in hormone dependent cells, and are constitutively increased in cells which acquire independence either spontaneously or by ras transfection. Collectively, the secreted growth factors are capable of promoting tumor formation by MCF-7 cells in nude mice, though not to the same extent as estrogens. There would seem to be potential for clinical intervention in the autocrine and paracrine control of breast cancer cells, including some cells which are no longer dependent on estrogens.
AB - We consider the hypothesis that estrogen control of hormone dependent breast cancer is mediated by autocrine and paracrine growth factors secreted by the breast cancer cells themselves. Though we show direct, unmediated effects of estrogen on specific cell functions, we also provide evidence that human breast cancer cells secrete a collection of growth factors (IGF-I, TGFα, TGFβ, a PDGF-like competency factor, and at least one new epithelial colony stimulating factor). Some of these are estrogen-regulated in hormone dependent cells, and are constitutively increased in cells which acquire independence either spontaneously or by ras transfection. Collectively, the secreted growth factors are capable of promoting tumor formation by MCF-7 cells in nude mice, though not to the same extent as estrogens. There would seem to be potential for clinical intervention in the autocrine and paracrine control of breast cancer cells, including some cells which are no longer dependent on estrogens.
KW - antiestrogen
KW - autocrine growth factors
KW - EGF
KW - hormone dependence
KW - IGF-I
KW - paracrine growth factors
KW - PDGF
KW - TGFα
KW - TGFβ
UR - http://www.scopus.com/inward/record.url?scp=0022649738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022649738&partnerID=8YFLogxK
U2 - 10.1007/BF01806790
DO - 10.1007/BF01806790
M3 - Article
C2 - 3013348
AN - SCOPUS:0022649738
VL - 7
SP - 59
EP - 70
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 2
ER -