TY - JOUR
T1 - Autoantibody titers to oxidized low-density lipoprotein in patients with coronary atherosclerosis
AU - Bui, Minh N.
AU - Sack, Michael N.
AU - Moutsatsos, George
AU - Lu, David Y.
AU - Katz, Paul
AU - McCown, Rosemary
AU - Breall, Jeffery A.
AU - Rackley, Charles E.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - Oxidation of low-density lipoprotein (LDL) is considered to be the initial step in the atherosclerotic process. Autoantibodies to oxidized LDL (ox-LDL) have been detected in human serum. We used an enzyme-linked immunosorbent assay technique to measure autoantibody titers in 63 normal subjects and patients with coronary artery disease. Thirty-five patients underwent coronary angiography for suspected coronary artery disease. Patients were divided into the following categories: group 1, 20 healthy young volunteers; group 2, 8 patients age-matched to the catheterization patients; group 3, 10 patients with normal coronary angiograms; and group 4, 25 patients with angiographic coronary artery disease. Autoantibody titers to ox-LDL were group 1, 0.142 ± 0.023; group 2, 0.197 ± 0.039; group 3, 0.183 ± 0.038; and group 4, 0.340 ± 0.026. There was no statistical difference among groups 1, 2, and 3, but the difference between these groups and group 4 was highly significant (p < 0.05). This study demonstrates that (1) autoantibodies to ox-LDL can be detected in normal subjects and in patients with abnormal coronary angiograms and (2) significantly higher titers of autoantibodies to ox-LDL were seen in patients with angiographic evidence of coronary artery disease.
AB - Oxidation of low-density lipoprotein (LDL) is considered to be the initial step in the atherosclerotic process. Autoantibodies to oxidized LDL (ox-LDL) have been detected in human serum. We used an enzyme-linked immunosorbent assay technique to measure autoantibody titers in 63 normal subjects and patients with coronary artery disease. Thirty-five patients underwent coronary angiography for suspected coronary artery disease. Patients were divided into the following categories: group 1, 20 healthy young volunteers; group 2, 8 patients age-matched to the catheterization patients; group 3, 10 patients with normal coronary angiograms; and group 4, 25 patients with angiographic coronary artery disease. Autoantibody titers to ox-LDL were group 1, 0.142 ± 0.023; group 2, 0.197 ± 0.039; group 3, 0.183 ± 0.038; and group 4, 0.340 ± 0.026. There was no statistical difference among groups 1, 2, and 3, but the difference between these groups and group 4 was highly significant (p < 0.05). This study demonstrates that (1) autoantibodies to ox-LDL can be detected in normal subjects and in patients with abnormal coronary angiograms and (2) significantly higher titers of autoantibodies to ox-LDL were seen in patients with angiographic evidence of coronary artery disease.
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U2 - 10.1016/S0002-8703(96)90268-9
DO - 10.1016/S0002-8703(96)90268-9
M3 - Article
C2 - 8721636
AN - SCOPUS:0029929276
VL - 131
SP - 663
EP - 667
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 4
ER -