Recent studies demonstrated that HMG-CoA reductase inhibitors slowed the progression and reduced the number of coronary events. Plaque stabilization has been proposed as an early beneficial mechanism. Nonisotopic ELISA technique was used to measure ox-LDL autoantibodies titers in 11 patients with hyperlipidemia LDL , IgG and IgM autoantibodies titers were measured at baseline and at 4 months after treatment with HMG-CoA reductase inhibitors. Baseline 4 months 12 months ofpauents 11 11 6 LDL(mg/dl) 173 ±37 138 ±28 128 ±15 Autoantibodies to ox-LDL<OD) IgG 0.138±0.076 0.154 + 0.087 0.180 + 0.071 IgM 0024 ±0.019 0.053± 0.044 p-valuc< 0.05 vs. baseline by paired Student t-test OD: optical density Six of the 11 patients had a 12-month follow-up with a mean IgG titer of 0.180 which was not significantly different from their baseline titer. There was no correlation between the magnitude of LDL reduction and changes in autoantibody titers. Conclusion: 1) With HMG-CoA reductase inhibitors, a decrease in LDL level was associated with an initial increase in autoantibodies titers to ox-LDL 2) Early increase in autoantibody titers was greater with IgM than IgG. 3) These early immune responses may be involved in plaque stabilization.
|Journal||Journal of Investigative Medicine|
|State||Published - Dec 1 1996|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)