Abstract
Antibodies to U1-RNP are part of the clinical definition of mixed connective tissue disease (MCTD). These antibodies and other well-defined antibodies tend to arise together in affected patients. Although still speculative, hypotheses that link U1-RNP antibodies to the development of autoimmunity in MCTD and that associate U1-RNP antibodies with mechanisms of tissue injury in MCTD have emerged and are being tested. Salient features of these hypotheses include: (1) an antigen-driven response that is due to impaired clearance of potentially immunogenic self-antigens, (2) inadequate B- and T-cell tolerance to RNP autoantigens, and (3) immunogenic properties of the RNA component of targeted ribonucleoproteins. Further studies are needed to establish whether anti-RNP antibodies have prognostic importance that is relevant to practicing clinicians.
| Original language | English |
|---|---|
| Pages (from-to) | 437-450 |
| Number of pages | 14 |
| Journal | Rheumatic Disease Clinics of North America |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 1 2005 |
Fingerprint
ASJC Scopus subject areas
- Rheumatology
Cite this
Autoantibodies in the pathogenesis of mixed connective tissue disease. / Greidinger, Eric L; Hoffman, Robert W.
In: Rheumatic Disease Clinics of North America, Vol. 31, No. 3, 01.08.2005, p. 437-450.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autoantibodies in the pathogenesis of mixed connective tissue disease
AU - Greidinger, Eric L
AU - Hoffman, Robert W.
PY - 2005/8/1
Y1 - 2005/8/1
N2 - Antibodies to U1-RNP are part of the clinical definition of mixed connective tissue disease (MCTD). These antibodies and other well-defined antibodies tend to arise together in affected patients. Although still speculative, hypotheses that link U1-RNP antibodies to the development of autoimmunity in MCTD and that associate U1-RNP antibodies with mechanisms of tissue injury in MCTD have emerged and are being tested. Salient features of these hypotheses include: (1) an antigen-driven response that is due to impaired clearance of potentially immunogenic self-antigens, (2) inadequate B- and T-cell tolerance to RNP autoantigens, and (3) immunogenic properties of the RNA component of targeted ribonucleoproteins. Further studies are needed to establish whether anti-RNP antibodies have prognostic importance that is relevant to practicing clinicians.
AB - Antibodies to U1-RNP are part of the clinical definition of mixed connective tissue disease (MCTD). These antibodies and other well-defined antibodies tend to arise together in affected patients. Although still speculative, hypotheses that link U1-RNP antibodies to the development of autoimmunity in MCTD and that associate U1-RNP antibodies with mechanisms of tissue injury in MCTD have emerged and are being tested. Salient features of these hypotheses include: (1) an antigen-driven response that is due to impaired clearance of potentially immunogenic self-antigens, (2) inadequate B- and T-cell tolerance to RNP autoantigens, and (3) immunogenic properties of the RNA component of targeted ribonucleoproteins. Further studies are needed to establish whether anti-RNP antibodies have prognostic importance that is relevant to practicing clinicians.
UR - http://www.scopus.com/inward/record.url?scp=23444451416&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23444451416&partnerID=8YFLogxK
U2 - 10.1016/j.rdc.2005.04.004
DO - 10.1016/j.rdc.2005.04.004
M3 - Article
C2 - 16084317
AN - SCOPUS:23444451416
VL - 31
SP - 437
EP - 450
JO - Rheumatic Disease Clinics of North America
JF - Rheumatic Disease Clinics of North America
SN - 0889-857X
IS - 3
ER -