Autoantibodies in the pathogenesis of mixed connective tissue disease

Eric L Greidinger, Robert W. Hoffman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Antibodies to U1-RNP are part of the clinical definition of mixed connective tissue disease (MCTD). These antibodies and other well-defined antibodies tend to arise together in affected patients. Although still speculative, hypotheses that link U1-RNP antibodies to the development of autoimmunity in MCTD and that associate U1-RNP antibodies with mechanisms of tissue injury in MCTD have emerged and are being tested. Salient features of these hypotheses include: (1) an antigen-driven response that is due to impaired clearance of potentially immunogenic self-antigens, (2) inadequate B- and T-cell tolerance to RNP autoantigens, and (3) immunogenic properties of the RNA component of targeted ribonucleoproteins. Further studies are needed to establish whether anti-RNP antibodies have prognostic importance that is relevant to practicing clinicians.

Original languageEnglish
Pages (from-to)437-450
Number of pages14
JournalRheumatic Disease Clinics of North America
Volume31
Issue number3
DOIs
StatePublished - Aug 1 2005

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Mixed Connective Tissue Disease
Autoantibodies
Antibodies
Ribonucleoproteins
Autoantigens
Autoimmunity
Anti-Idiotypic Antibodies
RNA
T-Lymphocytes
Antigens
Wounds and Injuries

ASJC Scopus subject areas

  • Rheumatology

Cite this

Autoantibodies in the pathogenesis of mixed connective tissue disease. / Greidinger, Eric L; Hoffman, Robert W.

In: Rheumatic Disease Clinics of North America, Vol. 31, No. 3, 01.08.2005, p. 437-450.

Research output: Contribution to journalArticle

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