Autism spectrum disorders: Linking neuropathological findings to treatment with transcranial magnetic stimulation

Manuel F. Casanova, Estate Sokhadze, Ioan Opris, Yao Wang, Xiaoli Li

Research output: Contribution to journalReview article

21 Scopus citations


Postmortem studies in autism spectrum disorder (ASD) individuals indicate the presence of abnormalities within the peripheral neuropil space (PNS) of cortical minicolumns. The geometrical orientation of inhibitory elements within the PNS suggests using repetitive transcranial magnetic stimulation (rTMS) to up-regulate their activity. Several rTMS trials in ASD have shown marked improvements in motor symptomatology, attention and perceptual binding.Conclusion: rTMS is the first therapeutic attempt at ASD aimed at correcting some of its core pathology.

Original languageEnglish (US)
Pages (from-to)346-355
Number of pages10
JournalActa Paediatrica, International Journal of Paediatrics
Issue number4
StatePublished - Apr 1 2015
Externally publishedYes



  • Autism spectrum disorder
  • Cerebral cortex
  • Minicolumn
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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