Augmenting cognitive training in older adults (The ACT Study): Design and Methods of a Phase III tDCS and cognitive training trial

Adam J. Woods, Ronald Cohen, Michael Marsiske, Gene E. Alexander, Sara J Czaja, Samuel Wu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Adults over age 65 represent the fastest growing population in the US. Decline in cognitive abilities is a hallmark of advanced age and is associated with loss of independence and dementia risk. There is a pressing need to develop effective interventions for slowing or reversing the cognitive aging process. While certain forms of cognitive training have shown promise in this area, effects only sometimes transfer to neuropsychological tests within or outside the trained domain. This paper describes a NIA-funded Phase III adaptive multisite randomized clinical trial, examining whether transcranial direct current stimulation (tDCS) of frontal cortices enhances neurocognitive outcomes achieved from cognitive training in older adults experiencing age-related cognitive decline: the Augmenting Cognitive Training in Older Adults study (ACT). Methods ACT will enroll 360 participants aged 65 to 89 with age-related cognitive decline, but not dementia. Participants will undergo cognitive training intervention or education training-control combined with tDCS or sham tDCS control. Cognitive training employs a suite of eight adaptive training tasks focused on attention/speed of processing and working memory from Posit Science BrainHQ. Training control involves exposure to educational nature/history videos and related content questions of the same interval/duration as the cognitive training. Participants are assessed at baseline, after training (12 weeks), and 12-month follow-up on our primary outcome measure, NIH Toolbox Fluid Cognition Composite Score, as well as a comprehensive neurocognitive, functional, clinical and multimodal neuroimaging battery. Significance The findings from this study have the potential to significantly enhance efforts to ameliorate cognitive aging and slow dementia.

Original languageEnglish (US)
Pages (from-to)19-32
Number of pages14
JournalContemporary Clinical Trials
Volume65
DOIs
StatePublished - Feb 1 2018

Fingerprint

Dementia
Aptitude
Neuropsychological Tests
Frontal Lobe
Short-Term Memory
Neuroimaging
Cognition
Randomized Controlled Trials
History
Outcome Assessment (Health Care)
Education
Population
Cognitive Dysfunction
Transcranial Direct Current Stimulation
Cognitive Aging
Transfer (Psychology)

Keywords

  • Adaptive randomized clinical trial design
  • Aging
  • Cognitive training
  • Phase III
  • tDCS
  • Transcranial direct current stimulation

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Augmenting cognitive training in older adults (The ACT Study) : Design and Methods of a Phase III tDCS and cognitive training trial. / Woods, Adam J.; Cohen, Ronald; Marsiske, Michael; Alexander, Gene E.; Czaja, Sara J; Wu, Samuel.

In: Contemporary Clinical Trials, Vol. 65, 01.02.2018, p. 19-32.

Research output: Contribution to journalArticle

Woods, Adam J. ; Cohen, Ronald ; Marsiske, Michael ; Alexander, Gene E. ; Czaja, Sara J ; Wu, Samuel. / Augmenting cognitive training in older adults (The ACT Study) : Design and Methods of a Phase III tDCS and cognitive training trial. In: Contemporary Clinical Trials. 2018 ; Vol. 65. pp. 19-32.
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