Auditory cortex lesions prevent the extinction of Pavlovian differential heart rate conditioning to tonal stimuli in rabbits

Alan H. Teich, Philip McCabe, Christopher C. Gentile, Laura S. Schneiderman, Ray Winters, David R. Liskowsky, Neil Schneiderman

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The present study examined the role of the auditory cortex in the extinction of differentially conditioned heart rate (HR) responses in rabbits. Lesions were placed bilaterally in wither the auditory cortex or the visual cortex. Three days after recovery from surgery, the auditory cortex lesion group and the visual cortex lesion control group were habituated to the tonal conditioned stimuli (CSs), and then given 2 days of Pavlovian differential conditioning (60 trials per day) in which one tone (CS+) was always paired with the unconditioned stimulus and another tone (CS-) was never paired with the uncondition stimulus. Animals that had demonstrated reliable differential conditioning (CS+ response at least 5 beats greater than the CS- response) were placed on an extinction schedule for 7 days. The extinction schedule was identical to the differential conditioning schedule with the exception that shock never followed the CS+. The results of the study indicate that auditory cortex lesions prevent the extinction of differential bradycardia conditioned responses (CRs) to tonal CSs. Whereas the bradycardia responses to the CS+ quickly extinguished in the group that had control lesions in the visual cortex, the auditory cortex lesion group continued to exhibit significantly larger bradycardiac HR CRs to the CS+ relative to the CS- during all 7 days of extinction. These results suggest that the animals in the auditory cortex lesioned group did not inhibit responses to a previously reinforced stimulus (i.e. CS+) as well as animals with control lesions in the visual cortex.

Original languageEnglish
Pages (from-to)210-218
Number of pages9
JournalBrain Research
Volume480
Issue number1-2
DOIs
StatePublished - Feb 20 1989

Fingerprint

Auditory Cortex
Heart Rate
Visual Cortex
Rabbits
Appointments and Schedules
Bradycardia
Control Groups
Shock

Keywords

  • Auditory cortex
  • Bradycardia
  • Differential Pavlovian conditioning
  • Extinction
  • Heart rate
  • Rabbit

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Auditory cortex lesions prevent the extinction of Pavlovian differential heart rate conditioning to tonal stimuli in rabbits. / Teich, Alan H.; McCabe, Philip; Gentile, Christopher C.; Schneiderman, Laura S.; Winters, Ray; Liskowsky, David R.; Schneiderman, Neil.

In: Brain Research, Vol. 480, No. 1-2, 20.02.1989, p. 210-218.

Research output: Contribution to journalArticle

Teich, Alan H. ; McCabe, Philip ; Gentile, Christopher C. ; Schneiderman, Laura S. ; Winters, Ray ; Liskowsky, David R. ; Schneiderman, Neil. / Auditory cortex lesions prevent the extinction of Pavlovian differential heart rate conditioning to tonal stimuli in rabbits. In: Brain Research. 1989 ; Vol. 480, No. 1-2. pp. 210-218.
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