Auditory brainstem responses in pervasive developmental disorders

J. M. Rumsey, A. M. Grimes, A. M. Pikus, R. Duara, D. R. Ismond

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Several studies have reported prolonged neural transmission times on auditory brainstem responses (ABRs) measured in autistic children, a finding which implicates CNS dysfunction at the level of the brainstem in autistic conditions. This study measured ABRs in 25 children and adults with pervasive developmental disorders (PDDs), including autism, and 25 age- and sex-matched normal controls. Subjects were carefully evaluated audiometrically and neurologically and artifact was controlled to produce highly reliable measures. Prolonged transmission times were seen in only one PDD subject and in one normal control, while shortened transmission times were seen in four PDD subjects. The majority of PDD subjects showed normal ABRs. Previous reports of a significant incidence of prolonged transmission times among autistic and autisticlike subjects, thus, were not replicated. Possible reasons for this discrepancy are discussed.

Original languageEnglish
Pages (from-to)1403-1418
Number of pages16
JournalBiological Psychiatry
Volume19
Issue number10
StatePublished - Dec 1 1984
Externally publishedYes

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Brain Stem Auditory Evoked Potentials
Autistic Disorder
Synaptic Transmission
Artifacts
Brain Stem
Incidence

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Rumsey, J. M., Grimes, A. M., Pikus, A. M., Duara, R., & Ismond, D. R. (1984). Auditory brainstem responses in pervasive developmental disorders. Biological Psychiatry, 19(10), 1403-1418.

Auditory brainstem responses in pervasive developmental disorders. / Rumsey, J. M.; Grimes, A. M.; Pikus, A. M.; Duara, R.; Ismond, D. R.

In: Biological Psychiatry, Vol. 19, No. 10, 01.12.1984, p. 1403-1418.

Research output: Contribution to journalArticle

Rumsey, JM, Grimes, AM, Pikus, AM, Duara, R & Ismond, DR 1984, 'Auditory brainstem responses in pervasive developmental disorders', Biological Psychiatry, vol. 19, no. 10, pp. 1403-1418.
Rumsey JM, Grimes AM, Pikus AM, Duara R, Ismond DR. Auditory brainstem responses in pervasive developmental disorders. Biological Psychiatry. 1984 Dec 1;19(10):1403-1418.
Rumsey, J. M. ; Grimes, A. M. ; Pikus, A. M. ; Duara, R. ; Ismond, D. R. / Auditory brainstem responses in pervasive developmental disorders. In: Biological Psychiatry. 1984 ; Vol. 19, No. 10. pp. 1403-1418.
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