Atypical propositional language organization in prenatal and early-acquired temporal lobe lesions

Brandon Korman, Byron Bernal, Michael Duchowny, Prasanna Jayakar, Nolan Altman, Genoveva Garaycoa, Trevor Resnick, Gustavo Rey

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

This study investigated differences in propositional language organization in children with developmental and acquired brain lesions. We evaluated 30 right-handed subjects with intractable epilepsy due to either focal cortical dysplasia or hippocampal sclerosis with neuropsychological testing and functional MRI prior to epilepsy surgery. Atypical activations were seen in both prenatal and early postnatal lesions, but the contribution of specific histopathological substrate was minimal. Atypical organization of both temporal and frontal language areas also correlated inversely with receptive vocabulary scores. The data demonstrated a greater propensity toward atypical activation patterns for receptive than expressive networks, particularly when lesions were located in the dominant temporal lobe. Atypical language organization was not correlated with seizure-related factors such as age at onset or duration of epilepsy. The patterns of atypical language activation support prior studies implicating proximity of pathology to eloquent cortex in the dominant hemisphere as the primary determinant of functional reorganization.

Original languageEnglish (US)
Pages (from-to)985-993
Number of pages9
JournalJournal of child neurology
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2010

Keywords

  • epilepsy
  • focal cortical dysplasia
  • functional MRI
  • hippocampal sclerosis
  • language organization
  • propositional language

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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