Atypical processing of novel distracters in a visual oddball task in autism spectrum disorder

Estate M. Sokhadze, Eva V. Lamina, Emily L. Casanova, Desmond P. Kelly, Ioan Opris, Irma Khachidze, Manuel F. Casanova

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Several studies have shown that children with autism spectrum disorder (ASD) show abnormalities in P3b to targets in standard oddball tasks. The present study employed a threestimulus visual oddball task with novel distracters that analyzed event-related potentials (ERP) to both target and non-target items at frontal and parietal sites. The task tested the hypothesis that children with autism are abnormally orienting attention to distracters probably due to impaired habituation to novelty. We predicted a lower selectivity in early ERPs to target, frequent non-target, and rare distracters. We also expected delayed late ERPs in autism. The study enrolled 32 ASD and 24 typically developing (TD) children. Reaction time (RT) and accuracy were analyzed as behavioral measures, while ERPs were recorded with a dense-array EEG system. Children with ASD showed higher error rate without normative post-error RT slowing and had lower error-related negativity. Parietal P1, frontal N1, as well as P3a and P3b components were higher to novels in ASD. Augmented exogenous ERPs suggest low selectivity in pre-processing of stimuli resulting in their excessive processing at later stages. The results suggest an impaired habituation to unattended stimuli that incurs a high load at the later stages of perceptual and cognitive processing and response selection when novel distracter stimuli are differentiated from targets.

Original languageEnglish (US)
Article number79
JournalBehavioral Sciences
Volume7
Issue number4
DOIs
StatePublished - Dec 1 2017

Fingerprint

autism
habituation
Autistic Disorder
Reaction Time
stimulus
abnormality
Evoked Potentials
Electroencephalography
selection response
Autism Spectrum Disorder
event

Keywords

  • Attention
  • Autism spectrum disorder
  • Cognitive processes
  • Event-related potential
  • Reaction time

ASJC Scopus subject areas

  • Psychology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Behavioral Neuroscience
  • Genetics
  • Development

Cite this

Sokhadze, E. M., Lamina, E. V., Casanova, E. L., Kelly, D. P., Opris, I., Khachidze, I., & Casanova, M. F. (2017). Atypical processing of novel distracters in a visual oddball task in autism spectrum disorder. Behavioral Sciences, 7(4), [79]. https://doi.org/10.3390/bs7040079

Atypical processing of novel distracters in a visual oddball task in autism spectrum disorder. / Sokhadze, Estate M.; Lamina, Eva V.; Casanova, Emily L.; Kelly, Desmond P.; Opris, Ioan; Khachidze, Irma; Casanova, Manuel F.

In: Behavioral Sciences, Vol. 7, No. 4, 79, 01.12.2017.

Research output: Contribution to journalArticle

Sokhadze, EM, Lamina, EV, Casanova, EL, Kelly, DP, Opris, I, Khachidze, I & Casanova, MF 2017, 'Atypical processing of novel distracters in a visual oddball task in autism spectrum disorder', Behavioral Sciences, vol. 7, no. 4, 79. https://doi.org/10.3390/bs7040079
Sokhadze, Estate M. ; Lamina, Eva V. ; Casanova, Emily L. ; Kelly, Desmond P. ; Opris, Ioan ; Khachidze, Irma ; Casanova, Manuel F. / Atypical processing of novel distracters in a visual oddball task in autism spectrum disorder. In: Behavioral Sciences. 2017 ; Vol. 7, No. 4.
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