Atypical NK-cell proliferation of the gastrointestinal tract in a patient with antigliadin antibodies but not celiac disease

Francisco Vega, Chung Che Chang, Mary R. Schwartz, Hector Alejandro Preti, Mamoun Younes, April Ewton, Ray Verm, Elaine S. Jaffe

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We describe a unique case of atypical natural killer (NK)-cell proliferation likely related to gluten sensitivity, mimicking NK-cell lymphoma. The patient, a 32-year-old man, has had persistent multiple erythematous bull-eye lesions in the stomach, small bowel, and large bowel for 3 years. Histologically, the lesions were well circumscribed and relatively superficial, composed of atypical medium-sized to large-sized lymphocytes with slightly irregular nuclear contours, a dispersed chromatin pattern, and clear cytoplasm. Immunohistochemistry and flow cytometry showed that the cells were NK cells expressing CD56 (aberrantly bright), T-cell intracellular antigen (TIA)-1, cytoplasmic CD3, and CD94, but not surface CD3, with bright aberrant expression of CD7 and a lack of other NK cell-associated markers. Polymerase chain reaction for rearrangement of the T-cell receptor-γ chain gene showed no evidence of a clonal T-cell population, and in situ hybridization for Epstein-Barr virus encoded RNA was negative. There was no evidence of the involvement of peripheral blood or bone marrow. Although a diagnosis of extranodal NK/T-cell lymphoma was considered because of the atypical morphology and immunophenotypic aberrancy, no chemotherapy was given because of the relatively superficial nature of the infiltrates, lack of significant symptoms, and negativity for Epstein-Barr virus. Two years after initial presentation, the patient was found to have high titers of antigliadin antibodies with no other evidence of celiac disease. After instituting a gluten-free diet, many of the lesions regressed, suggesting that this atypical NK-cell proliferation may be driven by an anomalous immune response. Awareness of this case may prevent pathologists from misdiagnosing similar lesions as NK/T-cell lymphomas. It is as yet unknown whether this process occurs more commonly in patients with gluten sensitivity, or in other settings, and the pathogenesis is as yet undetermined.

Original languageEnglish
Pages (from-to)539-544
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume30
Issue number4
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

Fingerprint

Celiac Disease
Natural Killer Cells
Gastrointestinal Tract
Cell Proliferation
Antibodies
Natural Killer T-Cells
Glutens
T-Cell Lymphoma
Human Herpesvirus 4
T-Lymphocytes
T-Cell Receptor Genes
Gluten-Free Diet
Diagnostic Errors
Chromatin
In Situ Hybridization
Lymphoma
Stomach
Flow Cytometry
Cytoplasm
Bone Marrow

Keywords

  • Atypical NK-cell proliferation
  • Celiac disease
  • Gastrointestinal tract

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Atypical NK-cell proliferation of the gastrointestinal tract in a patient with antigliadin antibodies but not celiac disease. / Vega, Francisco; Chang, Chung Che; Schwartz, Mary R.; Preti, Hector Alejandro; Younes, Mamoun; Ewton, April; Verm, Ray; Jaffe, Elaine S.

In: American Journal of Surgical Pathology, Vol. 30, No. 4, 01.04.2006, p. 539-544.

Research output: Contribution to journalArticle

Vega, Francisco ; Chang, Chung Che ; Schwartz, Mary R. ; Preti, Hector Alejandro ; Younes, Mamoun ; Ewton, April ; Verm, Ray ; Jaffe, Elaine S. / Atypical NK-cell proliferation of the gastrointestinal tract in a patient with antigliadin antibodies but not celiac disease. In: American Journal of Surgical Pathology. 2006 ; Vol. 30, No. 4. pp. 539-544.
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