Atypical lipomatous tumor mimicking giant fibrovascular polyp of the esophagus

Report of a case and a critical review of literature

Andrea Boni, Mikhail Lisovsky, Paola Dal Cin, Andrew Rosenberg, Amitabh Srivastava

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

An 81-year-old man presented to the emergency department with a mass protruding from his mouth after an episode of emesis. A computed tomography scan showed a hypodense, polypoid structure with a fatty component. The long polyp was attached by a narrow stalk to the cervical esophagus. A 14.0-cm slender mass resembling a giant fibrovascular polyp (GFP) of the esophagus was resected. The microscopic, immunohistochemical, and molecular findings were, however, those of an atypical lipomatous tumor (ALT). Atypical lipomatous tumor of the esophagus is a rare, low-grade malignant neoplasm, with a potential for local recurrence and, in most instances, presents as a large intraluminal polyp mimicking a GFP. Cases reported in the literature as primary myxoid liposarcomas of the esophagus are in all likelihood examples of ALT with myxoid change. A recent case reported as a GFP with karyotypic abnormalities on comparative genomic hybridization is also most likely to be an ALT mimicking a GFP. Pathologists need to be aware of the pitfalls in the diagnosis of ALT of the esophagus and should carefully evaluate the adipocytic component of these lesions.

Original languageEnglish
Pages (from-to)1165-1170
Number of pages6
JournalHuman Pathology
Volume44
Issue number6
DOIs
StatePublished - Jun 1 2013

Fingerprint

Polyps
Esophagus
Neoplasms
Myxoid Liposarcoma
Comparative Genomic Hybridization
Vomiting
Mouth
Hospital Emergency Service
Tomography
Recurrence

Keywords

  • Atypical lipomatous tumor
  • CDK4
  • Esophagus
  • Fibrovascular polyp
  • Liposarcoma
  • MDM2

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Atypical lipomatous tumor mimicking giant fibrovascular polyp of the esophagus : Report of a case and a critical review of literature. / Boni, Andrea; Lisovsky, Mikhail; Cin, Paola Dal; Rosenberg, Andrew; Srivastava, Amitabh.

In: Human Pathology, Vol. 44, No. 6, 01.06.2013, p. 1165-1170.

Research output: Contribution to journalArticle

Boni, Andrea ; Lisovsky, Mikhail ; Cin, Paola Dal ; Rosenberg, Andrew ; Srivastava, Amitabh. / Atypical lipomatous tumor mimicking giant fibrovascular polyp of the esophagus : Report of a case and a critical review of literature. In: Human Pathology. 2013 ; Vol. 44, No. 6. pp. 1165-1170.
@article{c808a01212dd447b8d9b9d21dfd82171,
title = "Atypical lipomatous tumor mimicking giant fibrovascular polyp of the esophagus: Report of a case and a critical review of literature",
abstract = "An 81-year-old man presented to the emergency department with a mass protruding from his mouth after an episode of emesis. A computed tomography scan showed a hypodense, polypoid structure with a fatty component. The long polyp was attached by a narrow stalk to the cervical esophagus. A 14.0-cm slender mass resembling a giant fibrovascular polyp (GFP) of the esophagus was resected. The microscopic, immunohistochemical, and molecular findings were, however, those of an atypical lipomatous tumor (ALT). Atypical lipomatous tumor of the esophagus is a rare, low-grade malignant neoplasm, with a potential for local recurrence and, in most instances, presents as a large intraluminal polyp mimicking a GFP. Cases reported in the literature as primary myxoid liposarcomas of the esophagus are in all likelihood examples of ALT with myxoid change. A recent case reported as a GFP with karyotypic abnormalities on comparative genomic hybridization is also most likely to be an ALT mimicking a GFP. Pathologists need to be aware of the pitfalls in the diagnosis of ALT of the esophagus and should carefully evaluate the adipocytic component of these lesions.",
keywords = "Atypical lipomatous tumor, CDK4, Esophagus, Fibrovascular polyp, Liposarcoma, MDM2",
author = "Andrea Boni and Mikhail Lisovsky and Cin, {Paola Dal} and Andrew Rosenberg and Amitabh Srivastava",
year = "2013",
month = "6",
day = "1",
doi = "10.1016/j.humpath.2012.10.023",
language = "English",
volume = "44",
pages = "1165--1170",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Atypical lipomatous tumor mimicking giant fibrovascular polyp of the esophagus

T2 - Report of a case and a critical review of literature

AU - Boni, Andrea

AU - Lisovsky, Mikhail

AU - Cin, Paola Dal

AU - Rosenberg, Andrew

AU - Srivastava, Amitabh

PY - 2013/6/1

Y1 - 2013/6/1

N2 - An 81-year-old man presented to the emergency department with a mass protruding from his mouth after an episode of emesis. A computed tomography scan showed a hypodense, polypoid structure with a fatty component. The long polyp was attached by a narrow stalk to the cervical esophagus. A 14.0-cm slender mass resembling a giant fibrovascular polyp (GFP) of the esophagus was resected. The microscopic, immunohistochemical, and molecular findings were, however, those of an atypical lipomatous tumor (ALT). Atypical lipomatous tumor of the esophagus is a rare, low-grade malignant neoplasm, with a potential for local recurrence and, in most instances, presents as a large intraluminal polyp mimicking a GFP. Cases reported in the literature as primary myxoid liposarcomas of the esophagus are in all likelihood examples of ALT with myxoid change. A recent case reported as a GFP with karyotypic abnormalities on comparative genomic hybridization is also most likely to be an ALT mimicking a GFP. Pathologists need to be aware of the pitfalls in the diagnosis of ALT of the esophagus and should carefully evaluate the adipocytic component of these lesions.

AB - An 81-year-old man presented to the emergency department with a mass protruding from his mouth after an episode of emesis. A computed tomography scan showed a hypodense, polypoid structure with a fatty component. The long polyp was attached by a narrow stalk to the cervical esophagus. A 14.0-cm slender mass resembling a giant fibrovascular polyp (GFP) of the esophagus was resected. The microscopic, immunohistochemical, and molecular findings were, however, those of an atypical lipomatous tumor (ALT). Atypical lipomatous tumor of the esophagus is a rare, low-grade malignant neoplasm, with a potential for local recurrence and, in most instances, presents as a large intraluminal polyp mimicking a GFP. Cases reported in the literature as primary myxoid liposarcomas of the esophagus are in all likelihood examples of ALT with myxoid change. A recent case reported as a GFP with karyotypic abnormalities on comparative genomic hybridization is also most likely to be an ALT mimicking a GFP. Pathologists need to be aware of the pitfalls in the diagnosis of ALT of the esophagus and should carefully evaluate the adipocytic component of these lesions.

KW - Atypical lipomatous tumor

KW - CDK4

KW - Esophagus

KW - Fibrovascular polyp

KW - Liposarcoma

KW - MDM2

UR - http://www.scopus.com/inward/record.url?scp=84878106033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878106033&partnerID=8YFLogxK

U2 - 10.1016/j.humpath.2012.10.023

DO - 10.1016/j.humpath.2012.10.023

M3 - Article

VL - 44

SP - 1165

EP - 1170

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 6

ER -