Atypical language representation in children with intractable temporal lobe epilepsy

Alice Maulisova, Brandon Korman, Gustavo Rey, Byron Bernal, Michael Duchowny, Marketa Niederlova, Pavel Krsek, Vilem Novak

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

This study evaluated language organization in children with intractable epilepsy caused by temporal lobe focal cortical dysplasia (FCD) alone or dual pathology (temporal lobe FCD and hippocampal sclerosis, HS). We analyzed clinical, neurological, fMRI, neuropsychological, and histopathologic data in 46 pediatric patients with temporal lobe lesions who underwent excisional epilepsy surgery. The frequency of atypical language representation was similar in both groups, but children with dual pathology were more likely to be left-handed. Atypical receptive language cortex correlated with lower intellectual capacity, verbal abstract conceptualization, receptive language abilities, verbal working memory, and a history of status epilepticus but did not correlate with higher seizure frequency or early seizure onset. Histopathologic substrate had only a minor influence on neuropsychological status. Greater verbal comprehension deficits were noted in children with atypical receptive language representation, a risk factor for cognitive morbidity.

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalEpilepsy and Behavior
Volume58
DOIs
StatePublished - May 1 2016

Keywords

  • Cognition
  • FCD
  • Handedness
  • Hippocampal sclerosis
  • Histopathology
  • Status epilepticus
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

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    Maulisova, A., Korman, B., Rey, G., Bernal, B., Duchowny, M., Niederlova, M., Krsek, P., & Novak, V. (2016). Atypical language representation in children with intractable temporal lobe epilepsy. Epilepsy and Behavior, 58, 91-96. https://doi.org/10.1016/j.yebeh.2016.03.006