TY - JOUR
T1 - Atypical language representation in children with intractable temporal lobe epilepsy
AU - Maulisova, Alice
AU - Korman, Brandon
AU - Rey, Gustavo
AU - Bernal, Byron
AU - Duchowny, Michael
AU - Niederlova, Marketa
AU - Krsek, Pavel
AU - Novak, Vilem
N1 - Funding Information:
This study was supported by GAUK 1162/13 , Faculty of Arts, Charles University , Prague, Czech Republic and MH CZ–DRO , University Hospital Motol, Prague, Czech Republic 00064203 . Disclosure The authors report no conflicts of interest.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - This study evaluated language organization in children with intractable epilepsy caused by temporal lobe focal cortical dysplasia (FCD) alone or dual pathology (temporal lobe FCD and hippocampal sclerosis, HS). We analyzed clinical, neurological, fMRI, neuropsychological, and histopathologic data in 46 pediatric patients with temporal lobe lesions who underwent excisional epilepsy surgery. The frequency of atypical language representation was similar in both groups, but children with dual pathology were more likely to be left-handed. Atypical receptive language cortex correlated with lower intellectual capacity, verbal abstract conceptualization, receptive language abilities, verbal working memory, and a history of status epilepticus but did not correlate with higher seizure frequency or early seizure onset. Histopathologic substrate had only a minor influence on neuropsychological status. Greater verbal comprehension deficits were noted in children with atypical receptive language representation, a risk factor for cognitive morbidity.
AB - This study evaluated language organization in children with intractable epilepsy caused by temporal lobe focal cortical dysplasia (FCD) alone or dual pathology (temporal lobe FCD and hippocampal sclerosis, HS). We analyzed clinical, neurological, fMRI, neuropsychological, and histopathologic data in 46 pediatric patients with temporal lobe lesions who underwent excisional epilepsy surgery. The frequency of atypical language representation was similar in both groups, but children with dual pathology were more likely to be left-handed. Atypical receptive language cortex correlated with lower intellectual capacity, verbal abstract conceptualization, receptive language abilities, verbal working memory, and a history of status epilepticus but did not correlate with higher seizure frequency or early seizure onset. Histopathologic substrate had only a minor influence on neuropsychological status. Greater verbal comprehension deficits were noted in children with atypical receptive language representation, a risk factor for cognitive morbidity.
KW - Cognition
KW - FCD
KW - Handedness
KW - Hippocampal sclerosis
KW - Histopathology
KW - Status epilepticus
KW - Temporal lobe epilepsy
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U2 - 10.1016/j.yebeh.2016.03.006
DO - 10.1016/j.yebeh.2016.03.006
M3 - Article
C2 - 27064828
AN - SCOPUS:84962743626
VL - 58
SP - 91
EP - 96
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
ER -