Atypical form of transient reactive papulotranslucent acrokeratoderma in a cystic fibrosis carrier

Katherine Baquerizo, Sadegh Amini, Jonette Keri, Evangelos V Badiavas, George Elgart

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report the first documented case of an atypical form of transient reactive papulotranslucent acrokeratoderma (TRPA) in a patient heterozygous for the ΔF508 CFTR(cystic fibrosis transmembrane conductance regulator) mutation. TRPA represents a condition that classically presents with translucent to white plaques that become evident after water exposure. An atypical form with persistent lesions has also been described. Our patient is a 16-year-old girl with small, white papules coalescing into pebbly plaques on the palms. This condition is exacerbated after 5-10 min of water exposure and is associated with discomfort. The skin biopsy showed expanded stratum corneum, orthohyperkeratosis and dilation of eccrine ducts consisting with TRPA. A cystic fibrosis carrier state, barrier function defect, hyperhidrosis and the intake of cyclooxygenase inhibitors may have been pathogenic factors in our patient.

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalJournal of Cutaneous Pathology
Volume40
Issue number4
DOIs
StatePublished - Apr 1 2013

Fingerprint

Cystic Fibrosis
Hyperhidrosis
Carrier State
Cystic Fibrosis Transmembrane Conductance Regulator
Cyclooxygenase Inhibitors
Water
Cornea
Dilatation
Biopsy
Skin
Mutation

Keywords

  • acrokeratoderma
  • atypical
  • cystic fibrosis
  • reactive

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine
  • Histology

Cite this

Atypical form of transient reactive papulotranslucent acrokeratoderma in a cystic fibrosis carrier. / Baquerizo, Katherine; Amini, Sadegh; Keri, Jonette; Badiavas, Evangelos V; Elgart, George.

In: Journal of Cutaneous Pathology, Vol. 40, No. 4, 01.04.2013, p. 413-418.

Research output: Contribution to journalArticle

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