Atypical form of transient reactive papulotranslucent acrokeratoderma in a cystic fibrosis carrier

Katherine Baquerizo, Sadegh Amini, Jonette E. Keri, Evangelos V. Badiavas, George W. Elgart

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We report the first documented case of an atypical form of transient reactive papulotranslucent acrokeratoderma (TRPA) in a patient heterozygous for the ΔF508 CFTR(cystic fibrosis transmembrane conductance regulator) mutation. TRPA represents a condition that classically presents with translucent to white plaques that become evident after water exposure. An atypical form with persistent lesions has also been described. Our patient is a 16-year-old girl with small, white papules coalescing into pebbly plaques on the palms. This condition is exacerbated after 5-10 min of water exposure and is associated with discomfort. The skin biopsy showed expanded stratum corneum, orthohyperkeratosis and dilation of eccrine ducts consisting with TRPA. A cystic fibrosis carrier state, barrier function defect, hyperhidrosis and the intake of cyclooxygenase inhibitors may have been pathogenic factors in our patient.

Original languageEnglish (US)
Pages (from-to)413-418
Number of pages6
JournalJournal of Cutaneous Pathology
Volume40
Issue number4
DOIs
StatePublished - Apr 1 2013

Keywords

  • acrokeratoderma
  • atypical
  • cystic fibrosis
  • reactive

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine
  • Histology

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