Atypical core-periphery brain dynamics in autism

Dipanjan Roy, Lucina Q. Uddin

Research output: Contribution to journalReview articlepeer-review

Abstract

The intrinsic function of the human brain is dynamic, giving rise to numerous behavioral subtypes that fluctuate distinctively at multiple timescales. One of the key dynamical processes that takes place in the brain is the interaction between core-periphery brain regions, which undergoes constant fluctuations associated with developmental time frames. Core-periphery dynamical changes associated with macroscale brain network dynamics span multiple timescales and may lead to atypical behavior and clinical symptoms. For example, recent evidence suggests that brain regions with shorter intrinsic timescales are located at the periphery of brain networks (e.g., sensorimotor hand, face areas) and are implicated in perception and movement. On the contrary, brain regions with longer timescales are core hub regions. These hubs are important for regulating interactions between the brain and the body during self-related cognition and emotion. In this review, we summarize a large body of converging evidence derived from time-resolved fMRI studies in autism to characterize atypical core-periphery brain dynamics and how they relate to core and contextual sensory and cognitive profiles.

Original languageEnglish (US)
Pages (from-to)295-321
Number of pages27
JournalNetwork Neuroscience
Volume5
Issue number2
DOIs
StatePublished - 2021

Keywords

  • Atypical timescales
  • Caudate
  • Core and contextual symptom severity
  • Core-periphery dynamics
  • Restricted and repetitive behaviors
  • Sensory-motor network

ASJC Scopus subject areas

  • Neuroscience(all)
  • Computer Science Applications
  • Artificial Intelligence
  • Applied Mathematics

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