Attentional predictors of clinical change during neuroleptic treatment in schizophrenia

Mark R. Serper, Michael Davidson, Philip D Harvey

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Improvement in auditory selective attention performance was examined in acute schizophrenic inpatients (n = 13) both off and on medication using the digit span distraction task. Subjects were tested at drug-free baseline and weekly for three weeks during treatment with haloperidol. Improvements in distractability preceded and predicted clinical improvements. A control group of stable schizophrenic outpatients (n = 12) medicated at all testing intervals were examined during the same time period. No significant clinical or attentional changes were found in the control group over the four testing intervals. These results suggest that specific types of attentional functions are intrinsically related to the biological processes affected by neuroleptic treatment and lend preliminary support to the contention that schizophrenic symptoms are mediated by attentional impairment.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalSchizophrenia Research
Volume13
Issue number1
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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Antipsychotic Agents
Schizophrenia
Biological Phenomena
Control Groups
Haloperidol
Inpatients
Outpatients
Therapeutics
Pharmaceutical Preparations

Keywords

  • (Schizophrenia)
  • Distractability
  • Neuroleptic
  • Selective attention

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)
  • Psychiatry and Mental health

Cite this

Attentional predictors of clinical change during neuroleptic treatment in schizophrenia. / Serper, Mark R.; Davidson, Michael; Harvey, Philip D.

In: Schizophrenia Research, Vol. 13, No. 1, 01.01.1994, p. 65-71.

Research output: Contribution to journalArticle

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