ATROPINE SELECTIVELY BLOCKS GHRH‐INDUCED GH SECRETION WITHOUT ALTERING LH, FSH, TSH, PRL AND ACTH/CORTISOL SECRETION ELICITED BY THEIR SPECIFIC HYPOTHALAMIC RELEASING FACTORS

F. F. CASANUEVA, L. VILLANUEVA, Y. DIAZ, J. DEVESA, A. FERNANDEZ‐CRUZ, A. V. SCHALLY

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The role of acetylcholine in the regulation of the hypothalamo-pituitary system in man was assessed using atropine, which selectively blocks cholinergic muscarinic receptors. Paired tests were performed in 10 normal men using either GHRH (1 μg/kg i.v.), or TRH (300 μg i.v.) plus LHRH (100 μg i.v.) plus corticotrophin releasing hormone (CRH) (1 μg/kg i.v.) with or without atropine given 30 min previously (1 mg i.m.). The GHRH-induced GH secretory peak (17.8 ± 3.0 ng/ml) was completely blocked by atropine administration (2.8 ± 0.6 ng/ml) (P < 0.05). Atropine did not, however, modify TRH-induced TSH and PRL secretion, nor FSH and LH release induced by the LHRH pulse. ACTH/cortisol secretion elicited by CRH was also unaffected by atropine. These results suggest that atropine blockade of GHRH-induced GH secretion is highly specific, and constitutes an indication of the importance of cholinergic control of GH function. Furthermore, atropine's lack of action on the other pituitary hormones rules out the possibility that it acts non-specifically, i.e. via blood flow changes or toxic effects.

Original languageEnglish (US)
Pages (from-to)319-323
Number of pages5
JournalClinical Endocrinology
Volume25
Issue number3
DOIs
StatePublished - Sep 1986
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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