Atrial vulnerability in the immature canine heart

Arthur S. Pickoff, Sharanjeet Singh, Celia J. Flinn, Jorge McCormack, Adrienne Stolfi, Henry Gelband

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The induction of repetitive atrial responses during atrial extrastimulation (atrial vulnerability) was studied in 3 groups of dogs. Group I consisted of 19 neonatal puppies (age 3 to 15 days), group II of 10 older puppies (age 5 to 11 weeks) and group III of 10 adult dogs. In all dogs, atrial extrastimulation was performed coupled to a constant paced rhythm that was 85 ± 7 % of the sinus cycle length at rest in group I,86 ± 6% in group II and 83 ± 10% in group III. In all groups, atrial repetitive responses were observed as the atrial functional refractory periods were approached during extrastimulation; however, the number of repetitive atrial responses was greater and the duration of repetitive firing longer in the neonates. In the neonatal group as many as 28 repetitive atrial responses were induced (9.4 ± 8.2 beats) and the duration of repetitive atrial firing averaged 838 ms (range 120 to 2,425). In contrast, in only 1 of 20 older puppies and adult dogs were more than 2 repetitive atrial beats observed (number of repetitive atrial beats in group II, 1.7 ± 1; in group III, 1.2 ± 0.5). Thus, the normal neonatal atrium is more susceptible to intraatrial reentry in response to premature extrastimulation than the more mature canine atrium. This enhanced atrial vulnerability may be related to the shorter atrial refractory periods of the neonate and may be of importance in understanding the genesis of certain dysrhythmias in the human neonate.

Original languageEnglish
Pages (from-to)1402-1406
Number of pages5
JournalThe American journal of cardiology
Volume55
Issue number11
DOIs
StatePublished - May 1 1985
Externally publishedYes

Fingerprint

Canidae
Dogs

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pickoff, A. S., Singh, S., Flinn, C. J., McCormack, J., Stolfi, A., & Gelband, H. (1985). Atrial vulnerability in the immature canine heart. The American journal of cardiology, 55(11), 1402-1406. https://doi.org/10.1016/0002-9149(85)90513-2

Atrial vulnerability in the immature canine heart. / Pickoff, Arthur S.; Singh, Sharanjeet; Flinn, Celia J.; McCormack, Jorge; Stolfi, Adrienne; Gelband, Henry.

In: The American journal of cardiology, Vol. 55, No. 11, 01.05.1985, p. 1402-1406.

Research output: Contribution to journalArticle

Pickoff, AS, Singh, S, Flinn, CJ, McCormack, J, Stolfi, A & Gelband, H 1985, 'Atrial vulnerability in the immature canine heart', The American journal of cardiology, vol. 55, no. 11, pp. 1402-1406. https://doi.org/10.1016/0002-9149(85)90513-2
Pickoff AS, Singh S, Flinn CJ, McCormack J, Stolfi A, Gelband H. Atrial vulnerability in the immature canine heart. The American journal of cardiology. 1985 May 1;55(11):1402-1406. https://doi.org/10.1016/0002-9149(85)90513-2
Pickoff, Arthur S. ; Singh, Sharanjeet ; Flinn, Celia J. ; McCormack, Jorge ; Stolfi, Adrienne ; Gelband, Henry. / Atrial vulnerability in the immature canine heart. In: The American journal of cardiology. 1985 ; Vol. 55, No. 11. pp. 1402-1406.
@article{60b69d9fa96343df9f5591398252585a,
title = "Atrial vulnerability in the immature canine heart",
abstract = "The induction of repetitive atrial responses during atrial extrastimulation (atrial vulnerability) was studied in 3 groups of dogs. Group I consisted of 19 neonatal puppies (age 3 to 15 days), group II of 10 older puppies (age 5 to 11 weeks) and group III of 10 adult dogs. In all dogs, atrial extrastimulation was performed coupled to a constant paced rhythm that was 85 ± 7 {\%} of the sinus cycle length at rest in group I,86 ± 6{\%} in group II and 83 ± 10{\%} in group III. In all groups, atrial repetitive responses were observed as the atrial functional refractory periods were approached during extrastimulation; however, the number of repetitive atrial responses was greater and the duration of repetitive firing longer in the neonates. In the neonatal group as many as 28 repetitive atrial responses were induced (9.4 ± 8.2 beats) and the duration of repetitive atrial firing averaged 838 ms (range 120 to 2,425). In contrast, in only 1 of 20 older puppies and adult dogs were more than 2 repetitive atrial beats observed (number of repetitive atrial beats in group II, 1.7 ± 1; in group III, 1.2 ± 0.5). Thus, the normal neonatal atrium is more susceptible to intraatrial reentry in response to premature extrastimulation than the more mature canine atrium. This enhanced atrial vulnerability may be related to the shorter atrial refractory periods of the neonate and may be of importance in understanding the genesis of certain dysrhythmias in the human neonate.",
author = "Pickoff, {Arthur S.} and Sharanjeet Singh and Flinn, {Celia J.} and Jorge McCormack and Adrienne Stolfi and Henry Gelband",
year = "1985",
month = "5",
day = "1",
doi = "10.1016/0002-9149(85)90513-2",
language = "English",
volume = "55",
pages = "1402--1406",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "11",

}

TY - JOUR

T1 - Atrial vulnerability in the immature canine heart

AU - Pickoff, Arthur S.

AU - Singh, Sharanjeet

AU - Flinn, Celia J.

AU - McCormack, Jorge

AU - Stolfi, Adrienne

AU - Gelband, Henry

PY - 1985/5/1

Y1 - 1985/5/1

N2 - The induction of repetitive atrial responses during atrial extrastimulation (atrial vulnerability) was studied in 3 groups of dogs. Group I consisted of 19 neonatal puppies (age 3 to 15 days), group II of 10 older puppies (age 5 to 11 weeks) and group III of 10 adult dogs. In all dogs, atrial extrastimulation was performed coupled to a constant paced rhythm that was 85 ± 7 % of the sinus cycle length at rest in group I,86 ± 6% in group II and 83 ± 10% in group III. In all groups, atrial repetitive responses were observed as the atrial functional refractory periods were approached during extrastimulation; however, the number of repetitive atrial responses was greater and the duration of repetitive firing longer in the neonates. In the neonatal group as many as 28 repetitive atrial responses were induced (9.4 ± 8.2 beats) and the duration of repetitive atrial firing averaged 838 ms (range 120 to 2,425). In contrast, in only 1 of 20 older puppies and adult dogs were more than 2 repetitive atrial beats observed (number of repetitive atrial beats in group II, 1.7 ± 1; in group III, 1.2 ± 0.5). Thus, the normal neonatal atrium is more susceptible to intraatrial reentry in response to premature extrastimulation than the more mature canine atrium. This enhanced atrial vulnerability may be related to the shorter atrial refractory periods of the neonate and may be of importance in understanding the genesis of certain dysrhythmias in the human neonate.

AB - The induction of repetitive atrial responses during atrial extrastimulation (atrial vulnerability) was studied in 3 groups of dogs. Group I consisted of 19 neonatal puppies (age 3 to 15 days), group II of 10 older puppies (age 5 to 11 weeks) and group III of 10 adult dogs. In all dogs, atrial extrastimulation was performed coupled to a constant paced rhythm that was 85 ± 7 % of the sinus cycle length at rest in group I,86 ± 6% in group II and 83 ± 10% in group III. In all groups, atrial repetitive responses were observed as the atrial functional refractory periods were approached during extrastimulation; however, the number of repetitive atrial responses was greater and the duration of repetitive firing longer in the neonates. In the neonatal group as many as 28 repetitive atrial responses were induced (9.4 ± 8.2 beats) and the duration of repetitive atrial firing averaged 838 ms (range 120 to 2,425). In contrast, in only 1 of 20 older puppies and adult dogs were more than 2 repetitive atrial beats observed (number of repetitive atrial beats in group II, 1.7 ± 1; in group III, 1.2 ± 0.5). Thus, the normal neonatal atrium is more susceptible to intraatrial reentry in response to premature extrastimulation than the more mature canine atrium. This enhanced atrial vulnerability may be related to the shorter atrial refractory periods of the neonate and may be of importance in understanding the genesis of certain dysrhythmias in the human neonate.

UR - http://www.scopus.com/inward/record.url?scp=0021849035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021849035&partnerID=8YFLogxK

U2 - 10.1016/0002-9149(85)90513-2

DO - 10.1016/0002-9149(85)90513-2

M3 - Article

VL - 55

SP - 1402

EP - 1406

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 11

ER -