Atrial natriuretic peptide clearance receptor agonist lowers pulmonary pressure in hypoxic rats

H. Jin, Y. F. Chen, R. H. Yang, R. M. Jackson, S. Oparil

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We demonstrated previously that intravenous administration of exogenous atrial natriuretic peptide (ANP) lowers mean pulmonary arterial pressure (MPAP) in hypoxia-adapted rats. To test the hypothesis that endogenous ANP may also lower MPAP in this model, C-ANP-(4-23), a ring-deleted analogue of ANP that binds to the biologically silent ANP clearance receptor (C-ANP receptor) but not to the ANP biological receptor (B-ANP receptor), was administered intravenously as a bolus injection (10 μg/kg) followed by an infusion (1 μg · kg-1 · min-1 for 60 min) to rats adapted to hypoxia (10% O2) for 4 wk and to air control rats. C-ANP-(4-23) significantly lowered MPAP in hypoxic rats but not in air controls. A statistically insignificant reduction in mean systemic arterial pressure was found in both groups after C-ANP-(4-23) administeration. C-ANP-(4-23) significantly (two- to threefold) increased endogenous plasma ANP levels in both groups; the increase was not significantly different between groups. Both basal and post-C-ANP-(4-23) levels of plasma ANP were greater in hypoxia-adapted animals than in air controls; the C-ANP-induced increase in plasma ANP was not significantly different between groups. These results suggest that the endogenous ANP may modulate pulmonary vascular tone in rats with hypoxic pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)2413-2418
Number of pages6
JournalJournal of applied physiology
Volume68
Issue number6
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • atrial natriuretic peptide clearance receptor
  • pulmonary circulation
  • pulmonary hypertension
  • silent-atrial natriuretic peptide receptors

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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