Atrial Myopathy Underlying Atrial Fibrillation

Research output: Contribution to journalArticlepeer-review

Abstract

While AF most often occurs in the setting of atrial disease, current assessment and treatment of patients with AF does not focus on the extent of the atrial myopathy that serves as the substrate for this arrhythmia. Atrial myopathy, in particular atrial fibrosis, may initiate a vicious cycle in which atrial myopathy leads to AF, which in turn leads to a worsening myopathy. Various techniques, including ECG, plasma biomarkers, electroanatomical voltage mapping, echocardiography, and cardiac MRI, can help to identify and quantify aspects of the atrial myopathy. Current therapies, such as catheter ablation, do not directly address the underlying atrial myopathy. There is emerging research showing that by targeting this myopathy we can help decrease the occurrence and burden of AF.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalArrhythmia and Electrophysiology Review
Volume9
Issue number2
DOIs
StatePublished - Jun 2020

Keywords

  • AF
  • Atrial fibrosis
  • Atrial myopathy
  • Cardiac MRI
  • Strain echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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