Atomoxetine treatment of ADHD in children with comorbid tourette syndrome

Thomas J. Spencer, F. Randy Sallee, Donald L. Gilbert, David W. Dunn, James T. McCracken, Barbara J. Coffey, Cathy L. Budman, Randall K. Ricardi, Henrietta L. Leonard, Albert J. Allen, Denai R. Milton, Peter D. Feldman, Douglas K. Kelsey, Daniel A. Geller, Steven L. Linder, Donald W. Lewis, Paul K. Winner, Roger M. Kurlan, Mark Mintz

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Objective: This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS). Method: Subjects (7-17 years old) with ADHD (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV) and TS were randomly assigned to double-blind treatment with placebo (n = 56) or atomoxetine (0.5-1.5 mg/kg/day, n = 61) for approximately 18 weeks. Results: Atomoxetine subjects showed significantly greater improvement on ADHD symptom measures. Treatment was also associated with significantly greater reduction of tic severity on two of three measures. Significant increases were seen in mean pulse rate and rates of treatment-emergent nausea, decreased appetite, and decreased body weight. No other clinically relevant treatment differences were observed in any other vital sign, adverse event, laboratory parameter, or electrocardiographic measure. Conclusion: Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS. (J. of Att. Dis. 2008; 11(4) 470-481).

Original languageEnglish (US)
Pages (from-to)470-481
Number of pages12
JournalJournal of Attention Disorders
Issue number4
StatePublished - Jan 2008
Externally publishedYes


  • ADHD
  • Atomoxetine
  • Tic disorders
  • Tourette syndrome

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology


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