Atherothrombosis: The role of tissue factor

Juan F. Viles-Gonzalez, Juan J. Badimon

Research output: Contribution to journalShort survey

20 Scopus citations

Abstract

Atherothrombosis, defined as atherosclerotic lesion disruption with superimposed thrombus formation, is the major cause of acute coronary syndromes and cardiovascular deaths. It is the leading cause of morbidity and mortality in the industrialized world. Plaque composition, rather than luminal stenosis, is recognized as the major determinant of this disease. Since tissue factor is found within atheroma and also in the bloodstream of atherosclerotic patients, it likely plays a key role in determining both plaque and blood thrombogenicity. Ongoing clinical and preclinical studies are evaluating the therapeutic possibilities of specific inhibition of the tissue factor pathway. Here, we will review the role of tissue factor in atherothrombosis.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalInternational Journal of Biochemistry and Cell Biology
Volume36
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • Antithrombotic therapy
  • Atherosclerosis
  • Atherothrombosis
  • Tissue factor
  • Tissue factor pathway inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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