Atherosclerosis within the non-neoplastic margin of partial nephrectomy specimens: Implications for medical management

Michael A. Gorin, Michael Garcia-Roig, Monica Garcia-Buitrago, Carlos Parra-Herran, Merce Jorda, Gaetano Ciancio

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Purpose: To describe the frequency and severity of atherosclerosis contained within the non-neoplastic tissue of partial nephrectomy (PN) specimens. Methods: Archived open PN specimens were evaluated for histological evidence of atherosclerosis. Clinically significant atherosclerosis was defined as arterial luminal narrowing of >25 % due to fibrointimal thickening. Histological findings were correlated with clinical data including history of major medical comorbidities and preoperative statin use. Results: The study cohort was comprised of 114 patients (71 men and 43 women). The mean age at the time of surgery was 59.3 years, and 69 (60.5 %) patients had a history of at least one major medical comorbidity including hypertension (54.5 %), diabetes (16.7 %) and coronary artery disease (12.3 %). Clinically significant atherosclerosis was observed in 29 (25.4 %) patients. These individuals were older (p = 0.001), and three times more likely to have greater than one major medical comorbidity (p = 0.002). In addition, only 17 (58.6 %) were prescribed a statin at the time of surgery. Conclusions: Atherosclerosis is frequently observed in the non-neoplastic tissue of PN specimens. Patients found to have atherosclerosis can potentially benefit from intensive lifestyle modification and medical therapy with lipid-lowering medications. These measures would likely have the greatest clinical impact on those patients without an existing history of major medical comorbidities.

Original languageEnglish (US)
Pages (from-to)1531-1534
Number of pages4
JournalWorld journal of urology
Volume31
Issue number6
DOIs
StatePublished - Dec 1 2013

Keywords

  • Atherosclerosis
  • Negative margin
  • Partial nephrectomy
  • Pathologic evaluation
  • Statin

ASJC Scopus subject areas

  • Urology

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