Atherosclerosis, inflammation, genetics, and stem cells

2012 update

Pascal Goldschmidt-Clermont, Chunming Dong, David M Seo, Omaida C Velazquez

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Atherosclerosis is a peculiar form of inflammation triggered by cholesterol-rich lipoproteins and other noxious factors such as cigarette smoke, diabetes mellitus, and hypertension. Genetics also play an important role in the disease, accounting for about 40% of the risk. Of surprise in recent years of post-human genome sequencing, atherosclerosis-relevant genes discovered by non-biased techniques (ie, genome-wide association studies), did not rehash previously suspected pathways of lipid metabolism, diabetes, or hypertension. Instead these studies highlighted genes relevant to mechanisms of inflammation and stem cell biology. Only a minority of implicated genes were linked to lipid and other cardiac risk factor genes. Although such findings do not contradict the fact that atherosclerosis is triggered and exacerbated by elevated lipids, atherosclerosis "new genes" suggest that themechanismresponsible for the development of arterial lesions is more complex than a simple response to injury, where injury is necessary, but perhaps not sufficient, for disease progression.

Original languageEnglish
Pages (from-to)201-210
Number of pages10
JournalCurrent Atherosclerosis Reports
Volume14
Issue number3
DOIs
StatePublished - Jun 1 2012

Fingerprint

Atherosclerosis
Stem Cells
Inflammation
Genes
Hypertension
Lipids
Genome-Wide Association Study
Wounds and Injuries
Human Genome
Lipid Metabolism
Smoke
Tobacco Products
Cell Biology
Disease Progression
Diabetes Mellitus

Keywords

  • Atherosclerosis
  • Genetics
  • Inflammation
  • Stem cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Atherosclerosis, inflammation, genetics, and stem cells : 2012 update. / Goldschmidt-Clermont, Pascal; Dong, Chunming; Seo, David M; Velazquez, Omaida C.

In: Current Atherosclerosis Reports, Vol. 14, No. 3, 01.06.2012, p. 201-210.

Research output: Contribution to journalArticle

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