Atenolol use is associated with long-term mortality in community-dwelling older adults with hypertension

Gianluca Testa, Francesco Cacciatore, David Della-Morte, Francesca Mazzella, Chiara Mastrobuoni, Gianluigi Galizia, Gaetano Gargiulo, Franco Rengo, Domenico Bonaduce, Pasquale Abete

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Aim: The role of atenolol, a non-vasodilating beta-blocker drug, on long-term mortality in hypertensive older adults is still unclear. The aim of the present study was to evaluate long-term mortality in community-dwelling hypertensive older adults taking atenolol. Methods: Long-term mortality after 12-year follow up in isolated hypertensive older adults (n=972) was analyzed. The patients were stratified in the presence and absence of atenolol use. Systolic, diastolic and pulse arterial pressure were measured. Results: Older adults taking atenolol showed a greater mortality and higher pulse arterial pressure values than those not taking atenolol (73.9% vs 55.0%; P=0.047 and 74.7±14.1 vs 63.0±14.2mmHg, P<0.001, respectively). Cox regression analysis showed that atenolol use (hazard risk 1.91; 95% confidence interval 1.04-4.31; P=0.04) and pulse arterial pressure (hazard risk 1.02; 95% confidence interval 1.01-1.03; P=0.032) were predictive of long-term mortality. Conclusions: Atenolol use was related to increased mortality in community-dwelling hypertensive Older adults. This increase in mortality risk seems to be related to an increase of pulse arterial pressure.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalGeriatrics and Gerontology International
Issue number1
StatePublished - Jan 2014
Externally publishedYes


  • Atenolol
  • Elderly
  • Hypertension
  • Long-term mortality
  • Pulse arterial pressure

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)


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