TY - JOUR
T1 - Asymptomatic and neurologically symptomatic HIV-seropositive subjects
T2 - Results of long-term MR imaging and clinical follow-up
AU - Post, M. Judith Donovan
AU - Berger, Joseph R.
AU - Duncan, Robert
AU - Quencer, Robert M.
AU - Pall, Lorraine
AU - Winfield, Dave
PY - 1993/9
Y1 - 1993/9
N2 - Cranial magnetic resonance (MR) images were prospectively obtained in 74 human immunodeficiency virus (HIV)-seropositive subjects, all of whom had undergone MR imaging 24-42 months earlier. The images were interpreted by neuroradiologists blinded to the subject's clinical status and were compared with the initial MR images and clinical findings. Ten subjects had mild neurologic symptoms, with mildly abnormal unchanged images in five (50%). Sixty-four subjects were neurologically asymptomatic, with mildly abnormal images in 13 (20%), most of which remained unchanged. χ2 analysis revealed a significant difference (P = .042) between the asymptomatic and symptomatic groups with regard to the number of subjects with abnormal follow-up images. The number of abnormal images in the asymptomatic subjects was significantly less than that in the symptomatic subjects. During follow-up of 2-31/2 years, most asymptomatic subjects had persistently normal MR images. When abnormal, the imaging abnormalities were usually static and minor.
AB - Cranial magnetic resonance (MR) images were prospectively obtained in 74 human immunodeficiency virus (HIV)-seropositive subjects, all of whom had undergone MR imaging 24-42 months earlier. The images were interpreted by neuroradiologists blinded to the subject's clinical status and were compared with the initial MR images and clinical findings. Ten subjects had mild neurologic symptoms, with mildly abnormal unchanged images in five (50%). Sixty-four subjects were neurologically asymptomatic, with mildly abnormal images in 13 (20%), most of which remained unchanged. χ2 analysis revealed a significant difference (P = .042) between the asymptomatic and symptomatic groups with regard to the number of subjects with abnormal follow-up images. The number of abnormal images in the asymptomatic subjects was significantly less than that in the symptomatic subjects. During follow-up of 2-31/2 years, most asymptomatic subjects had persistently normal MR images. When abnormal, the imaging abnormalities were usually static and minor.
KW - Acquired immunodeficiency syndrome (AIDS), 10.206
KW - Brain, atrophy, 10.83
KW - Brain, infection, 10.20
KW - Brain, white matter, 10.87
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U2 - 10.1148/radiology.188.3.8351340
DO - 10.1148/radiology.188.3.8351340
M3 - Article
C2 - 8351340
AN - SCOPUS:0027312887
VL - 188
SP - 727
EP - 733
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
ER -