Asymmetrical contribution of brain structures to treatment-resistant depression as illustrated by effects of right subgenual cingulum stimulation

Salvador M. Guinjoan, Helen S. Mayberg, Elsa Y. Costanzo, Rodolfo D. Fahrer, Eduardo Tenca, Julio Antico, Daniel Cerquetti, Elisa Smyth, Ramón C. Leiguarda, Charles B. Nemeroff

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Major depressive disorder is one of the most common psychiatric disorders, with a worldwide lifetime prevalence rate of 10%-20% in women and a slightly lower rate in men. While many patients are successfully treated using established therapeutic strategies, a significant percentage of patients fail to respond. This report describes the successful recovery of a previously treatment-resistant patient following right unilateral deep brain stimulation of Brodmann's area 25. Current therapeutic approaches to treatment-resistant patients are reviewed in the context of this case with an emphasis on the role of the right and left hemispheres in mediating disease pathogenesis and clinical recovery.

Original languageEnglish (US)
Pages (from-to)265-277
Number of pages13
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume22
Issue number3
DOIs
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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