Asymmetric somatosensory activation with right- vs left-hand stimulation: a positron emission tomographic study

Fumihito Yoshii, Myron D. Ginsberg, Roger E. Kelley, Jen Y. Chang, Warren W. Barker, Gary Ingenito, Anthony M. Apicella, Mordecai Y.T. Globus, Ranjan Duara, Thomas E. Boothe

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Metabolic activation of the right and left somatosensory cortices (SSC) in response to an active sensorimotor task (palpation and sorting of mah jongg tiles) was studied in 16 right-handed normal volunteers using positron emission tomography (PET) and a double-injection [18F]fluorodeoxyglucose strategy. In 8 subjects with right-hand stimulation, cerebral metabolic rate for glucose (CMRglc) in the contralateral SSC increased by 16.7 ± 5.1% (mean ± S.D.); the increase in the ipsilateral SSC was 4.8 ± 3.2% In contrast, in the 8 subjects with left-hand stimulation, the contralateral increase was 12.0 ± 2.9% and the ipsilateral increase was 5.9 ± 1.5%. Thus, contralateral SSC activation was significantly higher with stimulation of the right hand, while the ipsilateral/contralateral symmetry of activation was greater when the left hand was stimulated.

Original languageEnglish (US)
Pages (from-to)355-360
Number of pages6
JournalBrain Research
Volume483
Issue number2
DOIs
StatePublished - Apr 3 1989

Keywords

  • Cerebral asymmetry
  • Cerebral dominance
  • Cerebral glucose utilization
  • Fluorodeoxyglucose
  • Handedness
  • Human
  • Positron emission tomography
  • Somatosensory system

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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    Yoshii, F., Ginsberg, M. D., Kelley, R. E., Chang, J. Y., Barker, W. W., Ingenito, G., Apicella, A. M., Globus, M. Y. T., Duara, R., & Boothe, T. E. (1989). Asymmetric somatosensory activation with right- vs left-hand stimulation: a positron emission tomographic study. Brain Research, 483(2), 355-360. https://doi.org/10.1016/0006-8993(89)90180-7