Asymmetric conjugate addition of silyl enol ethers catalyzed by tethered bis(8-quinolinolato) aluminum complexes

Norito Takenaka, Joshua P. Abell, Hisashi Yamamoto

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

New chiral tethered bis(8-quinolinolato) (TBOx) aluminum(III) complexes effectively catalyze the highly enantioselective Mukaiyama-Michael reaction of silyl enol ethers, including tetrasubstituted enolates that give rise to enantioenriched α-carbonyl all-carbon-substituted quaternary stereocenters. The present catalyst also promotes the conjugate addition of N-benzylindole to α,β-unsaturated acylphosphonates with high enantioselectivity (indole Friedel-Crafts alkylation reaction).

Original languageEnglish (US)
Pages (from-to)742-743
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number4
DOIs
StatePublished - Jan 31 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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