Astroglial nuclear factor-κB regulates learning and memory and synaptic plasticity in female mice

Valerie Bracchi-Ricard, Roberta Brambilla, Jonathan Levenson, Wen Hui Hu, Annmarie Bramwell, J. David Sweatt, Edward J. Green, John R Bethea

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Astrocytes play a pivotal role in regulating synaptic plasticity and synapse formation. The nuclear factor-kappa B (NF-κB) family of transcription factors has recently been demonstrated to be an important modulator of synaptic plasticity and learning/memory. In this study, we investigated the role of astroglial NF-κB in synaptic plasticity and learning/memory using transgenic mice over-expressing an N-terminal truncated form of inhibitor of NF-κB alpha (IκBα) in astrocytes (GFAP-IκBα-dn). We demonstrated that female transgenic mice, but not males, have robust deficits in hippocampal and extra-hippocampal-dependent learning and memory. We also determined that there are significant deficits in LTP and expression of metabotropic glutamate receptor 5 and post-synaptic density protein 95 (PSD95) in female transgenic mice. These findings indicate that astroglial NF-κB is an important regulator of learning/memory and synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)611-623
Number of pages13
JournalJournal of neurochemistry
Volume104
Issue number3
DOIs
StatePublished - Feb 1 2008

Keywords

  • Astrocyte
  • Gender
  • Learning
  • Memory
  • NF-κB

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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