Astroglial nuclear factor-κB regulates learning and memory and synaptic plasticity in female mice

Valerie Bracchi-Ricard, Roberta Brambilla, Jonathan Levenson, Wen Hui Hu, Annmarie Bramwell, J. David Sweatt, Edward J. Green, John R. Bethea

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Astrocytes play a pivotal role in regulating synaptic plasticity and synapse formation. The nuclear factor-kappa B (NF-κB) family of transcription factors has recently been demonstrated to be an important modulator of synaptic plasticity and learning/memory. In this study, we investigated the role of astroglial NF-κB in synaptic plasticity and learning/memory using transgenic mice over-expressing an N-terminal truncated form of inhibitor of NF-κB alpha (IκBα) in astrocytes (GFAP-IκBα-dn). We demonstrated that female transgenic mice, but not males, have robust deficits in hippocampal and extra-hippocampal-dependent learning and memory. We also determined that there are significant deficits in LTP and expression of metabotropic glutamate receptor 5 and post-synaptic density protein 95 (PSD95) in female transgenic mice. These findings indicate that astroglial NF-κB is an important regulator of learning/memory and synaptic plasticity.

Original languageEnglish
Pages (from-to)611-623
Number of pages13
JournalJournal of Neurochemistry
Volume104
Issue number3
DOIs
StatePublished - Feb 1 2008

Fingerprint

Neuronal Plasticity
NF-kappa B
Plasticity
Learning
Transgenic Mice
Data storage equipment
Astrocytes
Metabotropic Glutamate 5 Receptor
Post-Synaptic Density
Synapses
Modulators
Transcription Factors
Proteins

Keywords

  • Astrocyte
  • Gender
  • Learning
  • Memory
  • NF-κB

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Astroglial nuclear factor-κB regulates learning and memory and synaptic plasticity in female mice. / Bracchi-Ricard, Valerie; Brambilla, Roberta; Levenson, Jonathan; Hu, Wen Hui; Bramwell, Annmarie; Sweatt, J. David; Green, Edward J.; Bethea, John R.

In: Journal of Neurochemistry, Vol. 104, No. 3, 01.02.2008, p. 611-623.

Research output: Contribution to journalArticle

Bracchi-Ricard, V, Brambilla, R, Levenson, J, Hu, WH, Bramwell, A, Sweatt, JD, Green, EJ & Bethea, JR 2008, 'Astroglial nuclear factor-κB regulates learning and memory and synaptic plasticity in female mice', Journal of Neurochemistry, vol. 104, no. 3, pp. 611-623. https://doi.org/10.1111/j.1471-4159.2007.04993.x
Bracchi-Ricard, Valerie ; Brambilla, Roberta ; Levenson, Jonathan ; Hu, Wen Hui ; Bramwell, Annmarie ; Sweatt, J. David ; Green, Edward J. ; Bethea, John R. / Astroglial nuclear factor-κB regulates learning and memory and synaptic plasticity in female mice. In: Journal of Neurochemistry. 2008 ; Vol. 104, No. 3. pp. 611-623.
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