Abstract
Astrocytic responses constitute one of the earliest and most prominent changes in the CNS following ischemic injury. Astrocytes are known to carry out critical functions such as maintenance of ionic homeostasis, prevention of excitotoxicity, scavenging free radicals, provision of nutrients and growth factors, promotion of neovascularization, and support of synaptogenesis and neurogenesis that potentially may influence the outcome of ischemic injury. This article reviews ischemia-associated alterations in astrocytes and their potential significance. Interactions with neurons, microglia, and endothelial cells are also considered. This article highlights the critical role of astrocytes in the CNS response to ischemic injury.
| Original language | English |
|---|---|
| Pages (from-to) | 287-298 |
| Number of pages | 12 |
| Journal | GLIA |
| Volume | 50 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jun 17 2005 |
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Keywords
- Anoxia-ischemia
- Astrocytosis
- Endothelial cells
- Microglia
- Neurons
ASJC Scopus subject areas
- Immunology
Cite this
Astrocytes in cerebral ischemic injury : Morphological and general considerations. / Panickar, Kiran S.; Norenberg, Michael D.
In: GLIA, Vol. 50, No. 4, 17.06.2005, p. 287-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Astrocytes in cerebral ischemic injury
T2 - Morphological and general considerations
AU - Panickar, Kiran S.
AU - Norenberg, Michael D
PY - 2005/6/17
Y1 - 2005/6/17
N2 - Astrocytic responses constitute one of the earliest and most prominent changes in the CNS following ischemic injury. Astrocytes are known to carry out critical functions such as maintenance of ionic homeostasis, prevention of excitotoxicity, scavenging free radicals, provision of nutrients and growth factors, promotion of neovascularization, and support of synaptogenesis and neurogenesis that potentially may influence the outcome of ischemic injury. This article reviews ischemia-associated alterations in astrocytes and their potential significance. Interactions with neurons, microglia, and endothelial cells are also considered. This article highlights the critical role of astrocytes in the CNS response to ischemic injury.
AB - Astrocytic responses constitute one of the earliest and most prominent changes in the CNS following ischemic injury. Astrocytes are known to carry out critical functions such as maintenance of ionic homeostasis, prevention of excitotoxicity, scavenging free radicals, provision of nutrients and growth factors, promotion of neovascularization, and support of synaptogenesis and neurogenesis that potentially may influence the outcome of ischemic injury. This article reviews ischemia-associated alterations in astrocytes and their potential significance. Interactions with neurons, microglia, and endothelial cells are also considered. This article highlights the critical role of astrocytes in the CNS response to ischemic injury.
KW - Anoxia-ischemia
KW - Astrocytosis
KW - Endothelial cells
KW - Microglia
KW - Neurons
UR - http://www.scopus.com/inward/record.url?scp=20344366326&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20344366326&partnerID=8YFLogxK
U2 - 10.1002/glia.20181
DO - 10.1002/glia.20181
M3 - Article
C2 - 15846806
AN - SCOPUS:20344366326
VL - 50
SP - 287
EP - 298
JO - GLIA
JF - GLIA
SN - 0894-1491
IS - 4
ER -