TY - JOUR
T1 - Associations of yersinia enterocolitica infection with autoimmune thyroid diseases
T2 - A systematic review and meta-analysis
AU - Zangiabadian, Moein
AU - Mirsaeidi, Mehdi
AU - Pooyafar, Mohammad H.
AU - Goudarzi, Mehdi
AU - Nasiri, Mohammad J.
N1 - Funding Information:
The authors would like to acknowledge the Shahid Beheshti University of Medical Sciences, Tehran, Iran, for supporting the study.
Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021
Y1 - 2021
N2 - Introduction: Yersinia enterocolitica infection is reportedly associated with the development of autoimmune thyroid diseases (AITD). However, evidence that such infection can lead to AITD is controversial. Thus, this study was aimed to investigate the associations of Y. enterocolitica infection with AITD. Methods: A meta-analysis was performed using PubMed, Web of Science, Embase and Cochrane library to identify relevant studies. The odds ratios (OR) and associated 95% confidence intervals [CI] were obtained. Data were analyzed by STATA 13.0 (Stata Corporation, College Station, TX, USA). Results: Of 215 articles identified, 8 studies with a total of 1490 participants met the criteria and were included in the meta-analysis. There was a significant association between Y. enterocolitica positivity and AITD (OR: 4.31 [CI 95%: 1.81–10.07], P-value: 0.00). According to the subgroup analysis, Y. enterocolitica infection statistically increased the risk of Graves' disease (GD) (OR: 6.12, [CI 95%: 3.71-10.10], P-value: 0.00). Likewise, the pooled OR of association between Y. enterocolitica positivity and hashimoto’s thyroiditis (HT) was 2.84 (CI 95%: 0.71-11.25, P-value: 0.1). Conclusion: The current studies suggest that Y. enterocolitica may be associated with the development of AITD. Further study is needed to explore the underlying mechanisms.
AB - Introduction: Yersinia enterocolitica infection is reportedly associated with the development of autoimmune thyroid diseases (AITD). However, evidence that such infection can lead to AITD is controversial. Thus, this study was aimed to investigate the associations of Y. enterocolitica infection with AITD. Methods: A meta-analysis was performed using PubMed, Web of Science, Embase and Cochrane library to identify relevant studies. The odds ratios (OR) and associated 95% confidence intervals [CI] were obtained. Data were analyzed by STATA 13.0 (Stata Corporation, College Station, TX, USA). Results: Of 215 articles identified, 8 studies with a total of 1490 participants met the criteria and were included in the meta-analysis. There was a significant association between Y. enterocolitica positivity and AITD (OR: 4.31 [CI 95%: 1.81–10.07], P-value: 0.00). According to the subgroup analysis, Y. enterocolitica infection statistically increased the risk of Graves' disease (GD) (OR: 6.12, [CI 95%: 3.71-10.10], P-value: 0.00). Likewise, the pooled OR of association between Y. enterocolitica positivity and hashimoto’s thyroiditis (HT) was 2.84 (CI 95%: 0.71-11.25, P-value: 0.1). Conclusion: The current studies suggest that Y. enterocolitica may be associated with the development of AITD. Further study is needed to explore the underlying mechanisms.
KW - Autoimmune thyroid diseases
KW - Graves' disease
KW - Hashimoto’s thyroiditis
KW - Meta-analysis
KW - Thyroid dysfunction
KW - Yersinia enterocolitica
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U2 - 10.2174/1871530320666200621180515
DO - 10.2174/1871530320666200621180515
M3 - Review article
C2 - 32564766
AN - SCOPUS:85105301275
VL - 21
SP - 682
EP - 687
JO - Endocrine, Metabolic and Immune Disorders - Drug Targets
JF - Endocrine, Metabolic and Immune Disorders - Drug Targets
SN - 1871-5303
IS - 4
ER -
