Associations of prenatal maternal blood mercury concentrations with early and mid-childhood blood pressure

A prospective study

Brian T. Kalish, Sheryl L. Rifas-Shiman, Robert O. Wright, Chitra J. Amarasiriwardena, Innocent Jayawardene, Matthew W. Gillman, Steven E Lipshultz, Emily Oken

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Childhood blood pressure (BP) is an important determinant of adult cardiovascular disease. Prenatal exposure to methylmercury through maternal fish consumption has been reported to increase the BP of children years later. Methods: Mother-child pairs were enrolled from Project Viva, a prospective cohort study in Massachusetts. From second trimester maternal blood samples, we measured erythrocyte mercury concentration. Systolic BP in children, measured up to 5 times per visit in early and mid-childhood (median ages 3.2 and 7.7 years), was the primary outcome. We used mixed-effect regression models to account for variation in the number of BP measurements and to average effects over both time points. Results: Among 1103 mother-child pairs, mean (SD) second trimester total erythrocyte mercury concentration was 4.0 (3.9). ng/g among mothers whose children were assessed in early childhood and 4.0 (4.0). ng/g for children assessed in mid-childhood. Mean (SD) offspring systolic BP was 92.1 (10.4). mm Hg in early childhood and 94.3 (8.4). mm Hg in mid-childhood. After adjusting for mother and infant characteristics, mean second trimester blood mercury concentration was not associated with child systolic BP (regression coefficient, 0.1. mm Hg; 95% CI, -1.3 to 1.5 for quartile 4 vs. quartile 1) at either time period. Further adjusting for second trimester maternal fish consumption, as well as docosahexaenoic acid and eicosapentaenoic acid consumption, did not substantially change the estimates. Conclusions: The results of this study demonstrate an absence of association between childhood blood pressure and low-level mercury exposure typical of the general US population.

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalEnvironmental Research
Volume133
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Blood pressure
Mercury
Blood
blood
Mothers
Prospective Studies
Blood Pressure
Second Pregnancy Trimester
Fish
Fishes
Eicosapentaenoic Acid
Erythrocytes
Docosahexaenoic Acids
Pressure measurement
mercury
acid
cardiovascular disease
methylmercury
fish
Hypotension

Keywords

  • Blood pressure
  • Mercury
  • Prenatal exposure

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry

Cite this

Kalish, B. T., Rifas-Shiman, S. L., Wright, R. O., Amarasiriwardena, C. J., Jayawardene, I., Gillman, M. W., ... Oken, E. (2014). Associations of prenatal maternal blood mercury concentrations with early and mid-childhood blood pressure: A prospective study. Environmental Research, 133, 327-333. https://doi.org/10.1016/j.envres.2014.06.004

Associations of prenatal maternal blood mercury concentrations with early and mid-childhood blood pressure : A prospective study. / Kalish, Brian T.; Rifas-Shiman, Sheryl L.; Wright, Robert O.; Amarasiriwardena, Chitra J.; Jayawardene, Innocent; Gillman, Matthew W.; Lipshultz, Steven E; Oken, Emily.

In: Environmental Research, Vol. 133, 01.01.2014, p. 327-333.

Research output: Contribution to journalArticle

Kalish, BT, Rifas-Shiman, SL, Wright, RO, Amarasiriwardena, CJ, Jayawardene, I, Gillman, MW, Lipshultz, SE & Oken, E 2014, 'Associations of prenatal maternal blood mercury concentrations with early and mid-childhood blood pressure: A prospective study', Environmental Research, vol. 133, pp. 327-333. https://doi.org/10.1016/j.envres.2014.06.004
Kalish, Brian T. ; Rifas-Shiman, Sheryl L. ; Wright, Robert O. ; Amarasiriwardena, Chitra J. ; Jayawardene, Innocent ; Gillman, Matthew W. ; Lipshultz, Steven E ; Oken, Emily. / Associations of prenatal maternal blood mercury concentrations with early and mid-childhood blood pressure : A prospective study. In: Environmental Research. 2014 ; Vol. 133. pp. 327-333.
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abstract = "Background: Childhood blood pressure (BP) is an important determinant of adult cardiovascular disease. Prenatal exposure to methylmercury through maternal fish consumption has been reported to increase the BP of children years later. Methods: Mother-child pairs were enrolled from Project Viva, a prospective cohort study in Massachusetts. From second trimester maternal blood samples, we measured erythrocyte mercury concentration. Systolic BP in children, measured up to 5 times per visit in early and mid-childhood (median ages 3.2 and 7.7 years), was the primary outcome. We used mixed-effect regression models to account for variation in the number of BP measurements and to average effects over both time points. Results: Among 1103 mother-child pairs, mean (SD) second trimester total erythrocyte mercury concentration was 4.0 (3.9). ng/g among mothers whose children were assessed in early childhood and 4.0 (4.0). ng/g for children assessed in mid-childhood. Mean (SD) offspring systolic BP was 92.1 (10.4). mm Hg in early childhood and 94.3 (8.4). mm Hg in mid-childhood. After adjusting for mother and infant characteristics, mean second trimester blood mercury concentration was not associated with child systolic BP (regression coefficient, 0.1. mm Hg; 95{\%} CI, -1.3 to 1.5 for quartile 4 vs. quartile 1) at either time period. Further adjusting for second trimester maternal fish consumption, as well as docosahexaenoic acid and eicosapentaenoic acid consumption, did not substantially change the estimates. Conclusions: The results of this study demonstrate an absence of association between childhood blood pressure and low-level mercury exposure typical of the general US population.",
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AU - Kalish, Brian T.

AU - Rifas-Shiman, Sheryl L.

AU - Wright, Robert O.

AU - Amarasiriwardena, Chitra J.

AU - Jayawardene, Innocent

AU - Gillman, Matthew W.

AU - Lipshultz, Steven E

AU - Oken, Emily

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N2 - Background: Childhood blood pressure (BP) is an important determinant of adult cardiovascular disease. Prenatal exposure to methylmercury through maternal fish consumption has been reported to increase the BP of children years later. Methods: Mother-child pairs were enrolled from Project Viva, a prospective cohort study in Massachusetts. From second trimester maternal blood samples, we measured erythrocyte mercury concentration. Systolic BP in children, measured up to 5 times per visit in early and mid-childhood (median ages 3.2 and 7.7 years), was the primary outcome. We used mixed-effect regression models to account for variation in the number of BP measurements and to average effects over both time points. Results: Among 1103 mother-child pairs, mean (SD) second trimester total erythrocyte mercury concentration was 4.0 (3.9). ng/g among mothers whose children were assessed in early childhood and 4.0 (4.0). ng/g for children assessed in mid-childhood. Mean (SD) offspring systolic BP was 92.1 (10.4). mm Hg in early childhood and 94.3 (8.4). mm Hg in mid-childhood. After adjusting for mother and infant characteristics, mean second trimester blood mercury concentration was not associated with child systolic BP (regression coefficient, 0.1. mm Hg; 95% CI, -1.3 to 1.5 for quartile 4 vs. quartile 1) at either time period. Further adjusting for second trimester maternal fish consumption, as well as docosahexaenoic acid and eicosapentaenoic acid consumption, did not substantially change the estimates. Conclusions: The results of this study demonstrate an absence of association between childhood blood pressure and low-level mercury exposure typical of the general US population.

AB - Background: Childhood blood pressure (BP) is an important determinant of adult cardiovascular disease. Prenatal exposure to methylmercury through maternal fish consumption has been reported to increase the BP of children years later. Methods: Mother-child pairs were enrolled from Project Viva, a prospective cohort study in Massachusetts. From second trimester maternal blood samples, we measured erythrocyte mercury concentration. Systolic BP in children, measured up to 5 times per visit in early and mid-childhood (median ages 3.2 and 7.7 years), was the primary outcome. We used mixed-effect regression models to account for variation in the number of BP measurements and to average effects over both time points. Results: Among 1103 mother-child pairs, mean (SD) second trimester total erythrocyte mercury concentration was 4.0 (3.9). ng/g among mothers whose children were assessed in early childhood and 4.0 (4.0). ng/g for children assessed in mid-childhood. Mean (SD) offspring systolic BP was 92.1 (10.4). mm Hg in early childhood and 94.3 (8.4). mm Hg in mid-childhood. After adjusting for mother and infant characteristics, mean second trimester blood mercury concentration was not associated with child systolic BP (regression coefficient, 0.1. mm Hg; 95% CI, -1.3 to 1.5 for quartile 4 vs. quartile 1) at either time period. Further adjusting for second trimester maternal fish consumption, as well as docosahexaenoic acid and eicosapentaenoic acid consumption, did not substantially change the estimates. Conclusions: The results of this study demonstrate an absence of association between childhood blood pressure and low-level mercury exposure typical of the general US population.

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