Associations of plasma cytokine and microbial translocation biomarkers with immune reconstitution inflammatory syndrome

Varghese George, Linda Harrison, Margaret Roach, Xiao Dong Li, Camlin Tierney, Margaret A. Fischl, Judith Aberg, Pablo Tebas, David M. Asmuth, Richard B. Pollard, Catherine Godfrey, Savita Pahwa

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fify-one of 1452 participants with baseline CD4 count < 350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.

Original languageEnglish (US)
Pages (from-to)1159-1163
Number of pages5
JournalJournal of Infectious Diseases
Volume216
Issue number9
DOIs
StatePublished - Nov 1 2017

Keywords

  • Cytokines
  • IRIS
  • Immune reconstitution inflammatory syndrome
  • Microbial translocation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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