Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome

AIDS Clinical Trials Group A5202 Study Team

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.

Original languageEnglish (US)
Pages (from-to)1159-1163
Number of pages5
JournalThe Journal of infectious diseases
Volume216
Issue number9
DOIs
StatePublished - Nov 27 2017

Keywords

  • cytokines
  • immune reconstitution inflammatory syndrome
  • IRIS
  • microbial translocation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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