Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

Christina M. Parrinello, Simin Hua, Mercedes R. Carnethon, Linda C. Gallo, Barry Hudson, Ronald B Goldberg, Alan M Delamater, Robert C. Kaplan, Carmen R. Isasi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. Methods: Among 1316 children 8-16. years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥. 48.1 and ≥. 2.02. ng/mL, respectively). Results: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p <. 0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). Conclusions: Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.

Original languageEnglish (US)
JournalJournal of Diabetes and its Complications
DOIs
StateAccepted/In press - Aug 23 2016

Fingerprint

Plasminogen Activator Inhibitor 1
Hispanic Americans
Hyperglycemia
Insulin Resistance
Biomarkers
E-Selectin
Fasting
Cardiovascular Diseases
Child Health
Glucose

Keywords

  • Adolescents/children
  • E-selectin
  • Hispanics
  • Hyyperglycemia
  • Insulin resistance
  • Plasminogen activator inhibitor-1

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

@article{51d84e6a27a64ac98b6ad4db3f873b77,
title = "Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)",
abstract = "Aims: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. Methods: Among 1316 children 8-16. years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95{\%} CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥. 48.1 and ≥. 2.02. ng/mL, respectively). Results: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p <. 0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95{\%} CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). Conclusions: Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.",
keywords = "Adolescents/children, E-selectin, Hispanics, Hyyperglycemia, Insulin resistance, Plasminogen activator inhibitor-1",
author = "Parrinello, {Christina M.} and Simin Hua and Carnethon, {Mercedes R.} and Gallo, {Linda C.} and Barry Hudson and Goldberg, {Ronald B} and Delamater, {Alan M} and Kaplan, {Robert C.} and Isasi, {Carmen R.}",
year = "2016",
month = "8",
day = "23",
doi = "10.1016/j.jdiacomp.2017.01.019",
language = "English (US)",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
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TY - JOUR

T1 - Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths

T2 - Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

AU - Parrinello, Christina M.

AU - Hua, Simin

AU - Carnethon, Mercedes R.

AU - Gallo, Linda C.

AU - Hudson, Barry

AU - Goldberg, Ronald B

AU - Delamater, Alan M

AU - Kaplan, Robert C.

AU - Isasi, Carmen R.

PY - 2016/8/23

Y1 - 2016/8/23

N2 - Aims: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. Methods: Among 1316 children 8-16. years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥. 48.1 and ≥. 2.02. ng/mL, respectively). Results: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p <. 0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). Conclusions: Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.

AB - Aims: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. Methods: Among 1316 children 8-16. years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥. 48.1 and ≥. 2.02. ng/mL, respectively). Results: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p <. 0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). Conclusions: Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.

KW - Adolescents/children

KW - E-selectin

KW - Hispanics

KW - Hyyperglycemia

KW - Insulin resistance

KW - Plasminogen activator inhibitor-1

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DO - 10.1016/j.jdiacomp.2017.01.019

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