Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection

Samuel B. Foster, Ming Lu, Daniel G. Glaze, James M. Reuben, Lynnette L. Harris, Evan N. Cohen, Bang Ning Lee, Enxu Zhao, Mary E. Paul, Heidi Schwarzwald, Chivon McMullen-Jackson, Charla Clark, F. Daniel Armstrong, Pim Y. Brouwers, Tracie L Miller, Andrew Colin, Gwendolyn B Scott, Shahriar Shahzeidi, Elizabeth J. Willen, Deshratn AsthanaSteven E Lipshultz, Bruce W. Thompson, William T. Shearer

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Youth infected with HIV at birth often have sleep disturbances, neurocognitive deficits, and abnormal psychosocial function which are associated with and possibly resulted from elevated blood cytokine levels that may lead to a decreased quality of life. To identify molecular pathways that might be associated with these disorders, we evaluated 38 HIV-infected and 35 uninfected subjects over 18-months for intracellular cytokine levels, sleep patterns and duration of sleep, and neurodevelopmental abilities. HIV infection was significantly associated with alterations of intracellular pro-inflammatory cytokines (TNF-α, IFN-γ, IL-12), sleep factors (total time asleep and daytime sleep patterns), and neurocognitive factors (parent and patient reported problems with socio-emotional, behavioral, and executive functions; working memory-mental fatigue; verbal memory; and sustained concentration and vigilance. By better defining the relationships between HIV infection, sleep disturbances, and poor psychosocial behavior and neurocognition, it may be possible to provide targeted pharmacologic and procedural interventions to improve these debilitating conditions.

Original languageEnglish
Pages (from-to)13-23
Number of pages11
JournalClinical Immunology
Volume144
Issue number1
DOIs
StatePublished - Jul 1 2012

Fingerprint

HIV Infections
Sleep
Cytokines
Mental Fatigue
HIV
Aptitude
Executive Function
Interleukin-12
Short-Term Memory
Quality of Life
Parturition

Keywords

  • Intracellular cytokines
  • Neurocognition
  • Neurodevelopment
  • Path analysis
  • Pediatric HIV infection
  • Sleep behavior

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Foster, S. B., Lu, M., Glaze, D. G., Reuben, J. M., Harris, L. L., Cohen, E. N., ... Shearer, W. T. (2012). Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection. Clinical Immunology, 144(1), 13-23. https://doi.org/10.1016/j.clim.2012.04.004

Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection. / Foster, Samuel B.; Lu, Ming; Glaze, Daniel G.; Reuben, James M.; Harris, Lynnette L.; Cohen, Evan N.; Lee, Bang Ning; Zhao, Enxu; Paul, Mary E.; Schwarzwald, Heidi; McMullen-Jackson, Chivon; Clark, Charla; Daniel Armstrong, F.; Brouwers, Pim Y.; Miller, Tracie L; Colin, Andrew; Scott, Gwendolyn B; Shahzeidi, Shahriar; Willen, Elizabeth J.; Asthana, Deshratn; Lipshultz, Steven E; Thompson, Bruce W.; Shearer, William T.

In: Clinical Immunology, Vol. 144, No. 1, 01.07.2012, p. 13-23.

Research output: Contribution to journalArticle

Foster, SB, Lu, M, Glaze, DG, Reuben, JM, Harris, LL, Cohen, EN, Lee, BN, Zhao, E, Paul, ME, Schwarzwald, H, McMullen-Jackson, C, Clark, C, Daniel Armstrong, F, Brouwers, PY, Miller, TL, Colin, A, Scott, GB, Shahzeidi, S, Willen, EJ, Asthana, D, Lipshultz, SE, Thompson, BW & Shearer, WT 2012, 'Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection', Clinical Immunology, vol. 144, no. 1, pp. 13-23. https://doi.org/10.1016/j.clim.2012.04.004
Foster, Samuel B. ; Lu, Ming ; Glaze, Daniel G. ; Reuben, James M. ; Harris, Lynnette L. ; Cohen, Evan N. ; Lee, Bang Ning ; Zhao, Enxu ; Paul, Mary E. ; Schwarzwald, Heidi ; McMullen-Jackson, Chivon ; Clark, Charla ; Daniel Armstrong, F. ; Brouwers, Pim Y. ; Miller, Tracie L ; Colin, Andrew ; Scott, Gwendolyn B ; Shahzeidi, Shahriar ; Willen, Elizabeth J. ; Asthana, Deshratn ; Lipshultz, Steven E ; Thompson, Bruce W. ; Shearer, William T. / Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection. In: Clinical Immunology. 2012 ; Vol. 144, No. 1. pp. 13-23.
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