Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events

Yiyi Zhang, Eric Vittinghoff, Mark J. Pletcher, Norrina B. Allen, Adina Zeki Al Hazzouri, Kristine Yaffe, Pallavi P. Balte, Alvaro Alonso, Anne B. Newman, Diane G. Ives, Jamal S. Rana, Donald Lloyd-Jones, Ramachandran S. Vasan, Kirsten Bibbins-Domingo, Holly C. Gooding, Sarah D. de Ferranti, Elizabeth C. Oelsner, Andrew E. Moran

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Blood pressure (BP) and cholesterol are major modifiable risk factors for cardiovascular disease (CVD), but effects of exposures during young adulthood on later life CVD risk have not been well quantified. Objective: The authors sought to evaluate the independent associations between young adult exposures to risk factors and later life CVD risk, accounting for later life exposures. Methods: The authors pooled data from 6 U.S. cohorts with observations spanning the life course from young adulthood to later life, and imputed risk factor trajectories for low-density lipoprotein (LDL) and high-density lipoprotein cholesterols, systolic and diastolic BP starting from age 18 years for every participant. Time-weighted average exposures to each risk factor during young (age 18 to 39 years) and later adulthood (age ≥40 years) were calculated and linked to subsequent risks of coronary heart disease (CHD), heart failure (HF), or stroke. Results: A total of 36,030 participants were included. During a median follow-up of 17 years, there were 4,570 CHD, 5,119 HF, and 2,862 stroke events. When young and later adult risk factors were considered jointly in the model, young adult LDL ≥100 mg/dl (compared with <100 mg/dl) was associated with a 64% increased risk for CHD, independent of later adult exposures. Similarly, young adult SBP ≥130 mm Hg (compared with <120 mm Hg) was associated with a 37% increased risk for HF, and young adult DBP ≥80 mm Hg (compared with <80 mm Hg) was associated with a 21% increased risk. Conclusions: Cumulative young adult exposures to elevated systolic BP, diastolic BP and LDL were associated with increased CVD risks in later life, independent of later adult exposures.

Original languageEnglish (US)
Pages (from-to)330-341
Number of pages12
JournalJournal of the American College of Cardiology
Volume74
Issue number3
DOIs
StatePublished - Jul 23 2019

Fingerprint

Cholesterol
Young Adult
Blood Pressure
Cardiovascular Diseases
LDL Lipoproteins
Coronary Disease
Heart Failure
Stroke
HDL Cholesterol

Keywords

  • blood pressure
  • cholesterol
  • coronary heart disease
  • heart failure
  • stroke
  • young adulthood

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events. / Zhang, Yiyi; Vittinghoff, Eric; Pletcher, Mark J.; Allen, Norrina B.; Zeki Al Hazzouri, Adina; Yaffe, Kristine; Balte, Pallavi P.; Alonso, Alvaro; Newman, Anne B.; Ives, Diane G.; Rana, Jamal S.; Lloyd-Jones, Donald; Vasan, Ramachandran S.; Bibbins-Domingo, Kirsten; Gooding, Holly C.; de Ferranti, Sarah D.; Oelsner, Elizabeth C.; Moran, Andrew E.

In: Journal of the American College of Cardiology, Vol. 74, No. 3, 23.07.2019, p. 330-341.

Research output: Contribution to journalArticle

Zhang, Y, Vittinghoff, E, Pletcher, MJ, Allen, NB, Zeki Al Hazzouri, A, Yaffe, K, Balte, PP, Alonso, A, Newman, AB, Ives, DG, Rana, JS, Lloyd-Jones, D, Vasan, RS, Bibbins-Domingo, K, Gooding, HC, de Ferranti, SD, Oelsner, EC & Moran, AE 2019, 'Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events', Journal of the American College of Cardiology, vol. 74, no. 3, pp. 330-341. https://doi.org/10.1016/j.jacc.2019.03.529
Zhang, Yiyi ; Vittinghoff, Eric ; Pletcher, Mark J. ; Allen, Norrina B. ; Zeki Al Hazzouri, Adina ; Yaffe, Kristine ; Balte, Pallavi P. ; Alonso, Alvaro ; Newman, Anne B. ; Ives, Diane G. ; Rana, Jamal S. ; Lloyd-Jones, Donald ; Vasan, Ramachandran S. ; Bibbins-Domingo, Kirsten ; Gooding, Holly C. ; de Ferranti, Sarah D. ; Oelsner, Elizabeth C. ; Moran, Andrew E. / Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events. In: Journal of the American College of Cardiology. 2019 ; Vol. 74, No. 3. pp. 330-341.
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abstract = "Background: Blood pressure (BP) and cholesterol are major modifiable risk factors for cardiovascular disease (CVD), but effects of exposures during young adulthood on later life CVD risk have not been well quantified. Objective: The authors sought to evaluate the independent associations between young adult exposures to risk factors and later life CVD risk, accounting for later life exposures. Methods: The authors pooled data from 6 U.S. cohorts with observations spanning the life course from young adulthood to later life, and imputed risk factor trajectories for low-density lipoprotein (LDL) and high-density lipoprotein cholesterols, systolic and diastolic BP starting from age 18 years for every participant. Time-weighted average exposures to each risk factor during young (age 18 to 39 years) and later adulthood (age ≥40 years) were calculated and linked to subsequent risks of coronary heart disease (CHD), heart failure (HF), or stroke. Results: A total of 36,030 participants were included. During a median follow-up of 17 years, there were 4,570 CHD, 5,119 HF, and 2,862 stroke events. When young and later adult risk factors were considered jointly in the model, young adult LDL ≥100 mg/dl (compared with <100 mg/dl) was associated with a 64{\%} increased risk for CHD, independent of later adult exposures. Similarly, young adult SBP ≥130 mm Hg (compared with <120 mm Hg) was associated with a 37{\%} increased risk for HF, and young adult DBP ≥80 mm Hg (compared with <80 mm Hg) was associated with a 21{\%} increased risk. Conclusions: Cumulative young adult exposures to elevated systolic BP, diastolic BP and LDL were associated with increased CVD risks in later life, independent of later adult exposures.",
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T1 - Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events

AU - Zhang, Yiyi

AU - Vittinghoff, Eric

AU - Pletcher, Mark J.

AU - Allen, Norrina B.

AU - Zeki Al Hazzouri, Adina

AU - Yaffe, Kristine

AU - Balte, Pallavi P.

AU - Alonso, Alvaro

AU - Newman, Anne B.

AU - Ives, Diane G.

AU - Rana, Jamal S.

AU - Lloyd-Jones, Donald

AU - Vasan, Ramachandran S.

AU - Bibbins-Domingo, Kirsten

AU - Gooding, Holly C.

AU - de Ferranti, Sarah D.

AU - Oelsner, Elizabeth C.

AU - Moran, Andrew E.

PY - 2019/7/23

Y1 - 2019/7/23

N2 - Background: Blood pressure (BP) and cholesterol are major modifiable risk factors for cardiovascular disease (CVD), but effects of exposures during young adulthood on later life CVD risk have not been well quantified. Objective: The authors sought to evaluate the independent associations between young adult exposures to risk factors and later life CVD risk, accounting for later life exposures. Methods: The authors pooled data from 6 U.S. cohorts with observations spanning the life course from young adulthood to later life, and imputed risk factor trajectories for low-density lipoprotein (LDL) and high-density lipoprotein cholesterols, systolic and diastolic BP starting from age 18 years for every participant. Time-weighted average exposures to each risk factor during young (age 18 to 39 years) and later adulthood (age ≥40 years) were calculated and linked to subsequent risks of coronary heart disease (CHD), heart failure (HF), or stroke. Results: A total of 36,030 participants were included. During a median follow-up of 17 years, there were 4,570 CHD, 5,119 HF, and 2,862 stroke events. When young and later adult risk factors were considered jointly in the model, young adult LDL ≥100 mg/dl (compared with <100 mg/dl) was associated with a 64% increased risk for CHD, independent of later adult exposures. Similarly, young adult SBP ≥130 mm Hg (compared with <120 mm Hg) was associated with a 37% increased risk for HF, and young adult DBP ≥80 mm Hg (compared with <80 mm Hg) was associated with a 21% increased risk. Conclusions: Cumulative young adult exposures to elevated systolic BP, diastolic BP and LDL were associated with increased CVD risks in later life, independent of later adult exposures.

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