Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality

Beverly H. Brummett, Andrew D. Krystal, Ilene C. Siegler, Cynthia Kuhn, Richard S. Surwit, Stephan L Zuchner, Allison Ashley-Koch, John C. Barefoot, Redford B. Williams

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

OBJECTIVE: To examine the relationships among the variable number of tandem repeats in the monoamine oxidase-A linked polymorphic region allelic variation (MAOA-uVNTR) and the symptoms of depression and sleep quality. The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. MAOA-uVNTR genotype has been associated with both psychological and physical measures. METHODS: The sample consisted of 74 males enrolled in a case/control study of caregivers for relatives with dementia. Age- and race-adjusted linear regression models were used to examine the association between low versus high MAOA-uVNTR activity alleles, symptoms of depression (Center for Epidemiological Studies of Depression), and sleep quality ratings (Pittsburgh Sleep Quality Index). RESULTS: MAOA-uVNTR alleles associated with less transcriptional activity were related to increased symptoms of depression (p < .04; Cohen's d = 0.52) and poorer sleep quality (p < .04; Cohen's d = 0.31). CONCLUSIONS: Individuals with less active MAOA-uVNTR alleles may be at increased risk for depressive symptoms and poor sleep.

Original languageEnglish
Pages (from-to)396-401
Number of pages6
JournalPsychosomatic Medicine
Volume69
Issue number5
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

Fingerprint

Monoamine Oxidase
Sleep
Depression
Genes
Alleles
Linear Models
Minisatellite Repeats
Genetic Promoter Regions
Caregivers
Neurotransmitter Agents
Dementia
Case-Control Studies
Epidemiologic Studies
Dopamine
Serotonin
Norepinephrine
Genotype
Psychology

Keywords

  • Depression
  • MAOA-uVNTR
  • Monoamine oxidase-A
  • Sleep

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. / Brummett, Beverly H.; Krystal, Andrew D.; Siegler, Ilene C.; Kuhn, Cynthia; Surwit, Richard S.; Zuchner, Stephan L; Ashley-Koch, Allison; Barefoot, John C.; Williams, Redford B.

In: Psychosomatic Medicine, Vol. 69, No. 5, 01.06.2007, p. 396-401.

Research output: Contribution to journalArticle

Brummett, BH, Krystal, AD, Siegler, IC, Kuhn, C, Surwit, RS, Zuchner, SL, Ashley-Koch, A, Barefoot, JC & Williams, RB 2007, 'Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality', Psychosomatic Medicine, vol. 69, no. 5, pp. 396-401. https://doi.org/10.1097/PSY.0b013e31806d040b
Brummett, Beverly H. ; Krystal, Andrew D. ; Siegler, Ilene C. ; Kuhn, Cynthia ; Surwit, Richard S. ; Zuchner, Stephan L ; Ashley-Koch, Allison ; Barefoot, John C. ; Williams, Redford B. / Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. In: Psychosomatic Medicine. 2007 ; Vol. 69, No. 5. pp. 396-401.
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AU - Surwit, Richard S.

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