Associations between neighborhood built environment and cognition vary by apolipoprotein E genotype: Multi-Ethnic Study of Atherosclerosis

Lilah Besser, James E. Galvin, Daniel Rodriguez, Teresa Seeman, Walter Kukull, Stephen R. Rapp, Jennifer Smith

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We examined whether neighborhood built environment (BE) and cognition associations in older adults vary by apolipoprotein E (APOE) genotype, a genetic risk factor for Alzheimer's disease (AD). We conducted a cross-sectional analysis of 4091 participants. Neighborhood characteristics included social and walking destination density (SDD, WDD), intersection density, and proportion of land dedicated to retail. Individuals were categorized as APOE ε2 (lower AD risk), APOE ε4 (higher AD risk), or APOE ε3 carriers. Among APOE ε2 carriers, greater proportion of land dedicated to retail was associated with better global cognition, and greater SDD, WDD, intersection density, and proportion of land dedicated to retail was associated with better processing speed. These associations were not observed in APOE ε3 or ε4 carriers. APOE ε2 carriers may be more susceptible to the potentially beneficial effects of denser neighborhood BEs on cognition; however, longitudinal studies are needed.

Original languageEnglish (US)
Article number102188
JournalHealth and Place
Volume60
DOIs
StatePublished - Nov 2019
Externally publishedYes

Keywords

  • Apolipoprotein E
  • Built environment
  • Cognition
  • Environment
  • Neighborhood
  • Older adults

ASJC Scopus subject areas

  • Health(social science)
  • Sociology and Political Science
  • Life-span and Life-course Studies

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