Associations between 20-Year Lipid Variability Throughout Young Adulthood and Midlife Cognitive Function and Brain Integrity

Adina Zeki Al Hazzouri, Michelle R. Caunca, Neal Jawadekar, Leslie Grasset, Tali Elfassy, Michelle C. Odden, Chenkai Wu, Martine Elbejjani, Lenore Launer, Kristine Yaffe

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Little is known about long-term lipid variability in young adulthood in relation to cognitive function and brain integrity in midlife. Method: We studied 3 328 adults from the Coronary Artery Risk Development in Young Adults. We defined low- and high-density lipoprotein (LDL and HDL) variability as the intraindividual standard deviation of lipid measurements over 20 years of young adulthood (1985-2005). Cognitive tests were administered in 2010. Brain scans were performed in 2010 on 714 participants. To facilitate comparison, cognitive tests and brain metrics were z-scored. Results: Mean age at baseline was 25.4 years. Higher 20-year LDL variability was associated with worse verbal memory in midlife (β = -0.25, 95% CI: -0.42, -0.08), adjusted for important covariates. Higher 20-year HDL variability was associated with worse processing speed in midlife (β = -0.80, 95% CI: -1.18, -0.41) and brain integrity, for example, smaller total brain volume (β = -0.58, 95% CI: -0.82, -0.34) and worse total brain fractional anisotropy (β = -1.13, 95% CI: -1.87, -0.39). Conclusions: Higher long-term lipid variability in adulthood was associated with worse cognition and brain integrity in midlife, in a relatively young cohort.

Original languageEnglish (US)
Pages (from-to)114-121
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume77
Issue number1
DOIs
StatePublished - Jan 1 2022
Externally publishedYes

Keywords

  • Brain
  • Cognition
  • Epidemiology
  • Homeostasis
  • Lipid

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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