Association studies between the plasmin genes and late-onset Alzheimer's disease

Nobuto Shibata, Toshitaka Kawarai, Yan Meng, Joseph H. Lee, Hye Seung Lee, Yosuke Wakutani, Eri Shibata, Nazia Pathan, Andrew Bi, Christine Sato, Sandro Sorbi, Amalia C. Bruni, Ranjan Duara, Richard Mayeux, Lindsay A. Farrer, Peter St George-Hyslop, Ekaterina Rogaeva

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The plasmin system is involved in the degradation of Aβ peptides, the accumulation of which in brain is a hallmark of Alzheimer's disease (AD). In a North European case-control AD dataset we studied 14 common variations in the PLG, PAI-1, PLAT and PLI genes encoding components of the plasmin system. Among the four polymorphisms in the PLAT, PAI-1 and PLI genes showing nominally significant evidence for an association with AD (allele p-value = 0.01-0.00003) the strongest association was detected for the deletion allele in the Alu-repeat region of the PLAT gene. However, none of these positive results were confirmed in follow-up studies using an independent Canadian case-control cohort and two familial AD datasets of North European and Caribbean Hispanic origin. Thus, the current survey does not support the notion that common polymorphisms in the plasmin genes influence the development of AD.

Original languageEnglish
Pages (from-to)1041-1043
Number of pages3
JournalNeurobiology of Aging
Volume28
Issue number7
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

    Fingerprint

Keywords

  • Alzheimer's disease
  • Plasmin
  • Polymorphism
  • Risk factor

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Shibata, N., Kawarai, T., Meng, Y., Lee, J. H., Lee, H. S., Wakutani, Y., Shibata, E., Pathan, N., Bi, A., Sato, C., Sorbi, S., Bruni, A. C., Duara, R., Mayeux, R., Farrer, L. A., George-Hyslop, P. S., & Rogaeva, E. (2007). Association studies between the plasmin genes and late-onset Alzheimer's disease. Neurobiology of Aging, 28(7), 1041-1043. https://doi.org/10.1016/j.neurobiolaging.2006.05.028